Yamamoto I, Watanabe K, Narimatsu S, Hamajima K, Yoshimura H
Eur J Pharmacol. 1985 May 8;111(2):159-66. doi: 10.1016/0014-2999(85)90752-6.
When a 5 mg/kg i.v. dose of delta 8-tetrahydrocannabinol (delta 8-THC) and 11-hydroxy-delta 8-tetrahydrocannabinol (11-OH-delta 8-THC) was administered daily to mice, tolerance to their hypothermic effects developed quickly. Cross-tolerance to the hypothermic effect also developed between delta 8-THC and 11-OH-delta 8-THC. Tolerance development was dose-dependent and dose-effect experiments indicated that the magnitude of the tolerance developed to 11-OH-delta 8-THC was greater than that to delta 8-THC. Both cannabinoids were cross-tolerant to chlorpromazine in the hypothermic effect, but not to morphine, pentobarbital and reserpine under the conditions used. The present results suggest that 11-OH-delta 8-THC has some role in the development of tolerance to the hypothermic effect of delta 8-THC in mice.
当每天给小鼠静脉注射5毫克/千克剂量的δ8-四氢大麻酚（δ8-THC）和11-羟基-δ8-四氢大麻酚（11-OH-δ8-THC）时，它们对低温效应的耐受性迅速产生。δ8-THC和11-OH-δ8-THC之间也产生了对低温效应的交叉耐受性。耐受性的产生具有剂量依赖性，剂量效应实验表明，对11-OH-δ8-THC产生的耐受性程度大于对δ8-THC产生的耐受性。在低温效应方面，两种大麻素对氯丙嗪都有交叉耐受性，但在所使用的条件下，对吗啡、戊巴比妥和利血平没有交叉耐受性。目前的结果表明，11-OH-δ8-THC在小鼠对δ8-THC低温效应耐受性的产生中起一定作用。
