Cabane J, Desmet V, Derenne J P, Similowski T, Launois S, Bizec J L, Orcel B
Service de Médecine Interne (Pr J. C. IMBERT), Hôpital Saint-Antoine, Paris.
Rev Med Interne. 1992 Nov;13(6):454-9. doi: 10.1016/s0248-8663(05)81547-4.
We report 18 cases of chronic hiccup (defined as lasting for more than 48 hours) in adults. Among the numerous possible causes, reflux esophagitis proved to be by far the most frequent (50% of the cases). However, hiccup often initiated a self-perpetuating vicious circle. This is possibly because hiccup per se can give esophageal dyskinesia, which in turn leads to gastro-esophageal reflux. The treatment was difficult and whenever possible has been directed chiefly towards the cause. However hiccup remained intractable in many cases even after a possible cause had been adequately cured (e.g., successful Nissen procedure in reflux cases). Central nervous system depressants and myorelaxing drugs were not very helpful, except for baclofen (initial response rate = 60%).
我们报告了18例成人慢性呃逆（定义为持续超过48小时）的病例。在众多可能的病因中，反流性食管炎是迄今为止最常见的病因（占病例的50%）。然而，呃逆常常引发一个自我持续的恶性循环。这可能是因为呃逆本身会导致食管运动障碍，进而导致胃食管反流。治疗困难，只要有可能，主要针对病因进行治疗。然而，即使在可能的病因得到充分治愈后（例如，反流病例中成功进行了nissen手术），呃逆在许多情况下仍然难以治疗。中枢神经系统抑制剂和肌松药物效果不佳，除了巴氯芬（初始有效率 = 60%）。
