Shay S S, Myers R L, Johnson L F
Gastroenterology. 1984 Jul;87(1):204-7.
A 67-yr-old man with protracted hiccups, as well as reflux esophagitis and a stricture, was found to have heartburn and water brash only during episodes of hiccups. Intraesophageal pH monitoring showed acid gastroesophageal reflux increased during these episodes and decreased with cessation of hiccups. After all attempts failed to relieve his hiccups, a Nissen fundoplication relieved heartburn, healed the esophagitis, and stopped excessive reflux of acid gastric juice, even though the hiccups persisted. These observations showed that reflux provoked by prolonged hiccups could either have adversely affected preexistent reflux esophagitis and stricture or conceivably could have caused these complications.
一名67岁男性患有持续性呃逆，同时伴有反流性食管炎和食管狭窄，仅在呃逆发作期间出现烧心和反酸。食管内pH监测显示，在这些发作期间，胃食管酸反流增加，呃逆停止时反流减少。在所有缓解呃逆的尝试均失败后，进行了nissen胃底折叠术，烧心症状得到缓解，食管炎愈合，胃酸过度反流停止，尽管呃逆仍持续存在。这些观察结果表明，长时间呃逆引发的反流可能对既往存在的反流性食管炎和狭窄产生了不利影响，或者可能导致了这些并发症。
