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关于印度古吉拉特邦凯达地区穆斯林和基督教社区中葡萄糖-6-磷酸脱氢酶(G-6-PD)缺乏症、镰状细胞血红蛋白及ABO血型与疟疾发病率关系的流行病学研究。

An epidemiological study of G-6-PD deficiency, sickle cell haemoglobin, and ABO blood groups in relation to malaria incidence in Muslim and Christian communities of Kheda, Gujarat, (India).

作者信息

Pant C S, Gupta D K, Bhatt R M, Gautam A S, Sharma R C

机构信息

Malaria Research Centre, Field Station, Civil Hospital, Nadiad.

出版信息

J Commun Dis. 1992 Dec;24(4):199-205.

PMID:1344953
Abstract

783 blood samples for the study of distribution of ABO blood groups and sickle cell haemoglobin in relation to malaria, from both the sexes of Muslim and Christian populations of Kheda district were screened. 414 blood samples from male individuals were screened for G-6-PD deficiency. High frequency of G-6-PD deficiency was observed in Christians (5.9%) and low in Muslim (1.8%) population, whereas sickle cell haemoglobin in Muslim population was 1.5% and absent in Christians. Blood group B was dominant in both the communities. Significant association of ABO polymorphs with P. falciparum and total malaria cases was observed.

摘要

对凯达地区穆斯林和基督教人口的男女783份血液样本进行了筛查,以研究ABO血型分布和镰状细胞血红蛋白与疟疾的关系。对414份男性个体的血液样本进行了葡萄糖-6-磷酸脱氢酶(G-6-PD)缺乏症筛查。观察到基督教人口中G-6-PD缺乏症的发生率较高(5.9%),而穆斯林人口中较低(1.8%),而穆斯林人口中镰状细胞血红蛋白为1.5%,基督教人口中则不存在。两个社区中B血型均占主导。观察到ABO多态性与恶性疟原虫及总疟疾病例之间存在显著关联。

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