Uneke C J
Department of Medical Microbiology, Faculty of Clinical Medicine, Ebonyi State University, Abakaliki, PMB 053, Nigeria.
Parasitol Res. 2007 Mar;100(4):759-65. doi: 10.1007/s00436-006-0342-5. Epub 2006 Oct 18.
There is increasing evidence that Plasmodium falciparum malaria is influenced by ABO blood group but the extent of association between both is yet to be well defined. Studies that investigated association between P. falciparum malaria and ABO blood group were identified using MEDLINE search and were systematically reviewed. There were apparent discrepancies and contradictions in the studies as some reported significant association between both while others observed no significant association. This outcome may reflect the complex interaction between P. falciparum malaria and the host immune responses. However, findings from all studies reviewed suggested that individuals of blood group O are relatively resistant to severe disease caused by P. falciparum infection. It was established that parasitized erythrocytes form rosettes more readily with red blood cells (RBCs) of A, B, or AB groups than with blood group O and this parasite-triggered RBC rosette formation is associated with the severity of clinical disease and with the development of cerebral malaria. Differences in rosetting ability were based on the P. falciparum strain-specific preference of rosetting with non-O blood groups and not only a phenomenon of laboratory-propagated strains, but also exist in wild clinical isolates from all major malarious areas of the world.
越来越多的证据表明，恶性疟原虫疟疾受ABO血型影响，但两者之间的关联程度尚未明确界定。通过医学文献数据库检索，确定了调查恶性疟原虫疟疾与ABO血型之间关联的研究，并进行了系统综述。这些研究存在明显的差异和矛盾，一些研究报告两者之间存在显著关联，而另一些研究则未观察到显著关联。这一结果可能反映了恶性疟原虫疟疾与宿主免疫反应之间的复杂相互作用。然而，所有综述研究的结果表明，O血型个体对恶性疟原虫感染引起的严重疾病相对具有抵抗力。已证实，被寄生的红细胞与A、B或AB血型的红细胞形成玫瑰花结的可能性比与O血型红细胞更高，这种寄生虫引发的红细胞玫瑰花结形成与临床疾病的严重程度以及脑型疟疾的发展有关。玫瑰花结形成能力的差异基于恶性疟原虫菌株对非O血型的特异性玫瑰花结形成偏好，这不仅是实验室繁殖菌株的现象，也存在于来自世界所有主要疟疾流行地区的野生临床分离株中。
