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黄连素,一种治疗沙眼的潜在药物。

Berberine, a potential drug for trachoma.

作者信息

Khosla P K, Neeraj V I, Gupta S K, Satpathy G

机构信息

Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi.

出版信息

Rev Int Trach Pathol Ocul Trop Subtrop Sante Publique. 1992;69:147-65.

PMID:1344968
Abstract

The clinical serological response to topical treatment of trachoma with Berberine an indigenous drug has been studied in 32 microbiologically confirmed cases. Efficacy of Berberine 0.2% when compared to sulfacetamide 20% was found to be superior in both the clinical course of trachoma and in achieving a fall in the serum antibody titers (P < 0.05) against chlamydia trachomatis in the treated patients.

摘要

在32例经微生物学确诊的病例中,研究了用国产药物黄连素局部治疗沙眼的临床血清学反应。与20%磺胺醋酰相比,0.2%黄连素在沙眼临床病程及使治疗患者沙眼衣原体血清抗体滴度下降方面均更具优势(P<0.05)。

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1
Berberine, a potential drug for trachoma.黄连素,一种治疗沙眼的潜在药物。
Rev Int Trach Pathol Ocul Trop Subtrop Sante Publique. 1992;69:147-65.
2
Berberine in trachoma. (A clinical trial).黄连素治疗沙眼(一项临床试验)。
Indian J Ophthalmol. 1982 Mar;30(2):69-75.
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Development of a macromolecular vaccine against experimental chlamydiosis and berberine--a new anti-trachoma agent.一种针对实验性衣原体病的大分子疫苗及小檗碱——一种新型抗沙眼药物的研发。
Rev Int Trach Pathol Ocul Trop Subtrop Sante Publique. 1985;62(1-2):103-16.
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Berberine: an indigenous drug in experimental herpetic uveitis.黄连素:实验性疱疹性葡萄膜炎中的一种本土药物。
Indian J Ophthalmol. 1983 Mar;31(2):65-8.
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Experimental study of the antitrachoma action of berberine.
Indian J Med Res. 1976 Aug;64(8):1160-7.
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Effect of berberine chloride eye drops on clinically positive trachoma patients.盐酸小檗碱滴眼液对临床确诊沙眼患者的疗效
Indian J Med Res. 1982 Dec;76 Suppl:83-8.
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Trachoma and ocular Chlamydia trachomatis were not eliminated three years after two rounds of mass treatment in a trachoma hyperendemic village.在一个沙眼高度流行村庄进行两轮大规模治疗三年后,沙眼和沙眼衣原体眼部感染并未消除。
Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1492-7. doi: 10.1167/iovs.06-0625.
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A double-blind comparison of picloxydine dihydrochloride (Vitabact eye drops) and sulfacetamide eye drops in the topical therapy of trachoma.盐酸匹洛昔定(维他巴滴眼液)与磺胺醋酰滴眼液治疗沙眼局部疗法的双盲比较
Rev Int Trach Pathol Ocul Trop Subtrop Sante Publique. 1988;65(3-4):119-32.
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Berberine.黄连素
Altern Med Rev. 2000 Apr;5(2):175-7.
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Constant ocular infection with Chlamydia trachomatis predicts risk of scarring in children in Tanzania.坦桑尼亚儿童沙眼衣原体持续眼部感染预示着瘢痕形成风险。
Ophthalmology. 2009 Feb;116(2):243-7. doi: 10.1016/j.ophtha.2008.09.011. Epub 2008 Dec 16.

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Chlamydial eye infections: Current perspectives.衣原体眼部感染:当前观点
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