Donatelli M, Verga S, Vaccaro M, Russo V, Bucalo M L, Scarpinato A
Istituto di Clinica Medica I, Università degli Studi, Palermo, Italy.
Diabetes Res. 1992;20(4):127-31.
Lipoprotein(a) [Lp(a)] has been added to the list of independent risk factors for cardiovascular disease (CVD), whose incidence is greater in obese subjects. There are few data available on the serum Lp(a) concentrations in obese individuals with or without insulin dependent diabetes mellitus (NIDDM). We selected 31 obese men with normal glucose tolerance (NGT) tests, 15 obese diabetic men, 14 non obese diabetic men and 17 healthy men as controls. We measured serum total cholesterol, HDL cholesterol, triglycerides, glucose, insulin and Lp(a). The mean Lp(a) levels in NGT obese men were 70.00 +/- 13.40 mg/l, which were similar to those found in normal controls (75.98 +/- 24.70 mg/l); significantly higher mean Lp(a) levels were found in obese diabetic men (168.84 +/- 56.43 mg/l) and in non obese diabetic men (240.85 +/- 63.35 mg/l). No significant correlation between Lp(a) levels and age, body mass index (BMI), total cholesterol, HDL cholesterol, triglycerides, insulin, was found; only a significant positive correlation between Lp(a) levels and glucose could be revealed (P < 0.05). Since higher levels of Lp(a) were found in NIDDM subjects with or without obesity, we conclude that hyperglycemia may influence the levels of serum Lp(a) facilitating its glycosylation in the liver with the consequence of a decline in its catabolic rate.
脂蛋白(a)[Lp(a)]已被列入心血管疾病(CVD)的独立危险因素清单，其在肥胖受试者中的发病率更高。关于患有或未患有胰岛素依赖型糖尿病(NIDDM)的肥胖个体的血清Lp(a)浓度，可用数据很少。我们选择了31名葡萄糖耐量正常(NGT)的肥胖男性、15名肥胖糖尿病男性、14名非肥胖糖尿病男性和17名健康男性作为对照。我们测量了血清总胆固醇、高密度脂蛋白胆固醇、甘油三酯、葡萄糖、胰岛素和Lp(a)。NGT肥胖男性的平均Lp(a)水平为70.00±13.40mg/l，与正常对照组(75.98±24.70mg/l)相似；肥胖糖尿病男性(168.84±56.43mg/l)和非肥胖糖尿病男性(240.85±63.35mg/l)的平均Lp(a)水平显著更高。未发现Lp(a)水平与年龄、体重指数(BMI)、总胆固醇、高密度脂蛋白胆固醇、甘油三酯、胰岛素之间存在显著相关性；仅发现Lp(a)水平与葡萄糖之间存在显著正相关(P<0.05)。由于在患有或未患有肥胖症的NIDDM受试者中发现了较高水平的Lp(a)，我们得出结论，高血糖可能会影响血清Lp(a)的水平，促进其在肝脏中的糖基化，从而导致其分解代谢率下降。
