肥胖女性及其一级亲属的心血管危险因素。

Cardiovascular risk factors in obese women and their first-degree relatives.

作者信息

Saraç Fulden, Ozgen Ahmet Gökhan, Yilmaz Candeğer, Tüzün Mehmet

机构信息

Department of Endocrinology and Metabolism, Faculty of Medicine, Ege University, Izmir, Turkey.

出版信息

Anadolu Kardiyol Derg. 2007 Dec;7(4):371-7.

PMID:18065331

Abstract

OBJECTIVE

Evidence for a connection between obesity and cardiovascular disease is derived from epidemiological studies. The aim of this study was to evaluate the cardiovascular risk factors in obese women and their first-degree relatives.

METHODS

Fifty-five obese women and their 154 first-degree relatives (daughter, son, sister, brother), 60 non-obese women and their 100 first-degree relatives were enrolled in this cross-sectional controlled study. Blood pressure, heart rate, body mass index (BMI), waist-to-hip ratio (WHpR), waist circumference (WC) and lipid levels were measured in all participants. Serum concentrations of insulin were measured by chemiluminescence method, plasma levels of high sensitive C-reactive protein (hs CRP) by immunoturbimetric assay and fibrinogen by coagulation method. Measurement of insulin resistance (IR) was calculated using homeostasis model assessment (HOMA). Statistical analysis was preformed using Chi-square, Student's t and Mann-Whitney U tests. The relationship between obesity indices and cardiovascular risk factors were studied using linear regression analysis.

RESULTS

Mean values of BMI in female and male relatives were found as 25.10+/-2.5 kg/m2 and 23.5+/-4.98 kg/m2, respectively. In relatives, the frequencies of obesity, overweight and normal weight were found to be 8.9%, 25.8% and 65.1%, respectively. Central obesity was found higher in males than in females in the first-degree relatives, using WC (28.5% vs. 14.3%, p=0.001) or WHpR (30.9% vs. 24.5%, p=0.002). Elevated blood pressure (>or=140/90 mmHg) was recorded in 23.6% of obese women and in 8.4% of their relatives. Mean HOMA-IR levels of obese women and their relatives were found as 3.26+/-0.7 and 2.07+/-1.1, respectively. Mean hs CRP levels of obese women and their relatives were 0.98+/-0.08 mg/dl and 0.23+/-0.03 mg/dl, respectively (p=0.002). Mean fibrinogen levels of obese women and their relatives were 443.21+/-45.9 mg/dl and 321.10+/-38.23 mg/dl, respectively.

CONCLUSION

In obese women and their relatives, body mass index and waist circumferences are related with blood pressure, total cholesterol, fibrinogen and insulin resistance. If there are obese women in family, first-degree relatives have 1.8 fold increased obesity frequency. Body mass index increases together with cardiovascular risk factors. In early term, prevention of obesity may decrease developing of cardiovascular risk.

摘要

目的

肥胖与心血管疾病之间存在关联的证据来源于流行病学研究。本研究的目的是评估肥胖女性及其一级亲属的心血管危险因素。

方法

本横断面对照研究纳入了55名肥胖女性及其154名一级亲属（女儿、儿子、姐妹、兄弟）、60名非肥胖女性及其100名一级亲属。测量了所有参与者的血压、心率、体重指数（BMI）、腰臀比（WHpR）、腰围（WC）和血脂水平。采用化学发光法测定血清胰岛素浓度，免疫比浊法测定血浆高敏C反应蛋白（hs CRP）水平，凝血法测定纤维蛋白原。使用稳态模型评估（HOMA）计算胰岛素抵抗（IR）。采用卡方检验、学生t检验和曼-惠特尼U检验进行统计分析。使用线性回归分析研究肥胖指数与心血管危险因素之间的关系。

结果

女性和男性亲属的BMI平均值分别为25.10±2.5 kg/m²和23.5±4.98 kg/m²。在亲属中，肥胖、超重和正常体重的频率分别为8.9%、25.8%和65.1%。在一级亲属中，使用WC（28.5%对14.3%，p = 0.001）或WHpR（30.9%对24.5%，p = 0.002）时，男性中心性肥胖高于女性。23.6%的肥胖女性及其8.4%的亲属血压升高（≥140/90 mmHg）。肥胖女性及其亲属的平均HOMA-IR水平分别为3.26±0.7和2.07±1.1。肥胖女性及其亲属的平均hs CRP水平分别为0.98±0.08 mg/dl和0.23±0.03 mg/dl（p = 0.002）。肥胖女性及其亲属的平均纤维蛋白原水平分别为443.21±45.9 mg/dl和321.10±38.23 mg/dl。