Altorjay I, Dalmi L, Sári B, Imre S, Balla G
2nd Department of Medicine, University Medical School, Debrecen, Hungary.
Acta Physiol Hung. 1992;80(1-4):375-80.
The effect of Legalon was investigated parallel with that of Adriblastina (doxorubicin) and paracetamol on some parameters characterizing the free radical scavenger mechanisms of human erythrocytes in vitro and on the time of acid hemolysis performed in aggregometer. Observations suggest that Adriblastina enhances the lipid peroxidation of the membrane of red blood cells, while paracetamol causes significant depletion of intracellular glutathione level, thus decreasing the free radical eliminating capacity of the glutathione peroxidase system. Legalon on the other hand, is able to increase the activity of both superoxide dismutase and glutathione peroxidase, which may explain the protective effect of the drug against free radicals and also the stabilizing effect on the red blood cell membrane, shown by the increase of the time of full haemolysis.
对水飞蓟宾（Legalon）与阿霉素（Adriblastina）和扑热息痛的效果进行了对比研究，观察它们对体外人红细胞自由基清除机制的一些特征参数以及在凝聚仪中进行酸溶血时间的影响。观察结果表明，阿霉素会增强红细胞膜的脂质过氧化作用，而扑热息痛会导致细胞内谷胱甘肽水平显著降低，从而降低谷胱甘肽过氧化物酶系统清除自由基的能力。另一方面，水飞蓟宾能够提高超氧化物歧化酶和谷胱甘肽过氧化物酶的活性，这或许可以解释该药物对自由基的保护作用，以及全溶血时间延长所显示的对红细胞膜的稳定作用。
