Muller H E, Krasemann C
Z Immunitatsforsch Exp Klin Immunol. 1976 Apr;151(3):237-41.
Neuraminidase may play a role as a pathogenic factor in Erysipelothrix rhusiopathiae infection. The protective effect of active immunization with purified neuraminidase was therefore tested in an infection experiment in white mice. Mice were immunized 2, 4, 6, 8 or 10 times i.p. with Erysipelothrix neuraminidase. A control group received 10 injections with physiological saline. The infective dose varied between 7 and 7 x 10(7) cells. While all control animals infected with 7 x 10(1) germs died, the lethal effect could be reduced to 50% and 25% in animals immunized twice and 4 times, respectively. Only animals immunized 8 and 10 times were still partly protected against germ numbers of 10(3)-10(4). Germ numbers of 10(5) and more were almost always fatal even in highly immunized animals. Even a high immunization with neuraminidase could only lower the lethal by a maximum factor of 10(4) germs used.
神经氨酸酶可能在猪丹毒丝菌感染中作为一种致病因素发挥作用。因此，在一项针对小白鼠的感染实验中测试了用纯化神经氨酸酶进行主动免疫的保护效果。小鼠经腹腔注射猪丹毒丝菌神经氨酸酶2、4、6、8或10次。一个对照组接受10次生理盐水注射。感染剂量在7至7×10⁷个细胞之间变化。当所有感染7×10¹个病菌的对照动物死亡时，在分别免疫两次和四次的动物中，致死效应可分别降低至50%和25%。只有免疫8次和10次的动物仍能部分抵御10³ - 10⁴个病菌数量。即使是10⁵及以上的病菌数量，即使在高度免疫的动物中几乎也总是致命的。即使对神经氨酸酶进行高剂量免疫，也只能将所用病菌的致死率最高降低10⁴倍。
