Winczyk K, Zerek-Mełeń G, Pawlikowski M
Department of Experimental Endocrinology and Hormone Diagnostics, Institute of Endocrinology, Medical Academy in Lódź.
Endokrynol Pol. 1992;43(1):73-77.
The effect of chronic metoclopramide administration (for 10 days at a daily dose of 5 mg/kg body weight subcutaneously) on cell proliferation in spleen and in thymus was investigated. Cell proliferation was evaluated by the stathmokinetic method with the use of vincristine. It was found that metoclopramide administration results in a statistically significant increase in the value of the mean mitotic activity rate index (MMAR) of splenocytes in the areas around arteries. At the same time no statistically significant changes were demonstrated in the MMAR index values obtained for splenocytes present in the germinal centers of the spleen. No significant changes in the MMAR index could also be found for thymocytes.
研究了慢性给予胃复安（每日剂量为5mg/kg体重，皮下注射10天）对脾脏和胸腺细胞增殖的影响。采用长春新碱通过静止动力学方法评估细胞增殖。结果发现，给予胃复安后，动脉周围区域脾细胞的平均有丝分裂活性率指数（MMAR）值有统计学意义的增加。同时，脾脏生发中心存在的脾细胞所获得的MMAR指数值未显示出统计学意义的变化。胸腺细胞的MMAR指数也未发现显著变化。
