• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Ribose conformations of 8-azapurine nucleosides in solution.

作者信息

Lüdemann H D, Westhof E, Cuno I

出版信息

Z Naturforsch C Biosci. 1976 Mar-Apr;31(3-4):135-40. doi: 10.1515/znc-1976-3-407.

DOI:10.1515/znc-1976-3-407
PMID:134555
Abstract

The ribose conformations of 8-azaadenosine, 8-azaguanosine, and 8-azainosine have been studied using proton magnetic resonance in ND3 solutions, in D2O solutions, and in pyridine solutions. The temperature was varied between -60 and +40 degrees C in ND3 and between +10 and +60 degrees C in D20 solutions. The analysis is based on the two state S in equilibrium N model of the ribose moiety proposed by Altona and Sundaralingam. In D2O, the 8-aza substitution destabilizes the gg rotamer and simultaneously diminishes the population of the S state of the ribose. It is deduced that the anti population of the base is greater in the 8-azapurine(beta)ribosides than in the common purine(beta)-ribosides.

摘要

相似文献

1
Ribose conformations of 8-azapurine nucleosides in solution.
Z Naturforsch C Biosci. 1976 Mar-Apr;31(3-4):135-40. doi: 10.1515/znc-1976-3-407.
2
Ribose conformations in the common purine(beta)ribosides, in some antibiotic nucleosides, and in some isopropylidene derivatives: a comparison.
Z Naturforsch C Biosci. 1975 Mar-Apr;30(2):131-40. doi: 10.1515/znc-1975-3-401.
3
Conformations of the nucleoside analogs formycin, 2-azaadenosine, and nebularine in solution.
Z Naturforsch C Biosci. 1977 Jul-Aug;32(7-8):528-38. doi: 10.1515/znc-1977-7-809.
4
Conformation of the common purine (beta) ribosides in solution: further evidence for a correlation between N-S state of the ribose moiety and syn-anti equilibrium.
Biophys Struct Mech. 1975 Feb 19;1(2):121-37. doi: 10.1007/BF00539774.
5
Molecular orbital studies on the structure of nucleoside analogs. I. Conformation of 8-azapurine nucleosides.
Biochim Biophys Acta. 1978 Jan 26;517(1):255-64. doi: 10.1016/0005-2787(78)90053-9.
6
Further evidence for a S-syn correlation in the purine(beta)ribosides: the solution conformation of two tricyclic analogs of adenosine and guanosine.
Z Naturforsch C Biosci. 1979 Sep-Oct;34(9-10):653-57. doi: 10.1515/znc-1979-9-1001.
7
Proton magnetic resonance studies of 2'-,3'-, and 5'-deoxyadenosine conformations in solution.溶液中2'-、3'-和5'-脱氧腺苷构象的质子磁共振研究。
Nucleic Acids Res. 1977 Apr;4(4):939-53. doi: 10.1093/nar/4.4.939.
8
Interrelation between glycosidic torsion, sugar pucker, and backbone conformation in 5'-beta-nucleotides. A 1H and 31P fast Fourier transform nuclear magnetic resonance investigation of the conformation of 8-aza-5'-beta-adenosine monophosphate and 8-aza-5'-beta-guanosine monophosphate.5'-β-核苷酸中糖苷扭转、糖环构象与主链构象之间的相互关系。8-氮杂-5'-β-腺苷单磷酸和8-氮杂-5'-β-鸟苷单磷酸构象的1H和31P快速傅里叶变换核磁共振研究。
J Biol Chem. 1975 Feb 25;250(4):1290-6.
9
Analogues of 8-azainosine.
J Med Chem. 1977 Jan;20(1):116-20. doi: 10.1021/jm00211a024.
10
C8-amino purine nucleosides. A well-defined steric determinant of glycosyl conformational preferences.
Biochim Biophys Acta. 1977 Jun 17;476(4):265-71. doi: 10.1016/0005-2787(77)90290-8.

引用本文的文献

1
Proton magnetic resonance studies of 2'-,3'-, and 5'-deoxyadenosine conformations in solution.溶液中2'-、3'-和5'-脱氧腺苷构象的质子磁共振研究。
Nucleic Acids Res. 1977 Apr;4(4):939-53. doi: 10.1093/nar/4.4.939.