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1
Proton magnetic resonance studies of 2'-,3'-, and 5'-deoxyadenosine conformations in solution.溶液中2'-、3'-和5'-脱氧腺苷构象的质子磁共振研究。
Nucleic Acids Res. 1977 Apr;4(4):939-53. doi: 10.1093/nar/4.4.939.
2
Solution conformational analysis of 2'-amino-2''deoxyadenosine, 3'-amino-3'-deoxyadenosine and puromycin by pulsed nuclear-magnetic-resonance methods.
Eur J Biochem. 1977 Oct 17;80(1):295-304. doi: 10.1111/j.1432-1033.1977.tb11882.x.
3
Ribose conformations of 8-azapurine nucleosides in solution.
Z Naturforsch C Biosci. 1976 Mar-Apr;31(3-4):135-40. doi: 10.1515/znc-1976-3-407.
4
Conformation of the common purine (beta) ribosides in solution: further evidence for a correlation between N-S state of the ribose moiety and syn-anti equilibrium.
Biophys Struct Mech. 1975 Feb 19;1(2):121-37. doi: 10.1007/BF00539774.
5
Ribose conformations in the common purine(beta)ribosides, in some antibiotic nucleosides, and in some isopropylidene derivatives: a comparison.
Z Naturforsch C Biosci. 1975 Mar-Apr;30(2):131-40. doi: 10.1515/znc-1975-3-401.
6
Further evidence for a S-syn correlation in the purine(beta)ribosides: the solution conformation of two tricyclic analogs of adenosine and guanosine.
Z Naturforsch C Biosci. 1979 Sep-Oct;34(9-10):653-57. doi: 10.1515/znc-1979-9-1001.
7
Conformations of the nucleoside analogs formycin, 2-azaadenosine, and nebularine in solution.
Z Naturforsch C Biosci. 1977 Jul-Aug;32(7-8):528-38. doi: 10.1515/znc-1977-7-809.
8
Solution structure of an oligodeoxynucleotide duplex containing the exocyclic lesion 3,N4-etheno-2'-deoxycytidine opposite 2'-deoxyadenosine, determined by NMR spectroscopy and restrained molecular dynamics.通过核磁共振光谱和受限分子动力学确定的含有3,N4-乙烯基-2'-脱氧胞苷（与2'-脱氧腺苷相对的环外损伤）的寡脱氧核苷酸双链体的溶液结构。
Biochemistry. 1996 Oct 15;35(41):13310-8. doi: 10.1021/bi9605696.
9
Nuclear magnetic resonance studies of 2'- and 3'-ribonucleotide structures in solution.溶液中2'-和3'-核糖核苷酸结构的核磁共振研究。
Biochemistry. 1975 Feb 11;14(3):543-54. doi: 10.1021/bi00674a013.
10
NMR solution structure of an oligodeoxynucleotide duplex containing the exocyclic lesion 3,N4-etheno-2'-deoxycytidine opposite thymidine: comparison with the duplex containing deoxyadenosine opposite the adduct.含有与胸腺嘧啶相对的环外损伤3,N4-乙烯基-2'-脱氧胞苷的寡脱氧核苷酸双链体的核磁共振溶液结构：与含有与加合物相对的脱氧腺苷的双链体的比较。
Biochemistry. 1996 Oct 15;35(41):13319-27. doi: 10.1021/bi9605705.

引用本文的文献

1
The sugar ring conformation of 4'-ethynyl-2-fluoro-2'-deoxyadenosine and its recognition by the polymerase active site of HIV reverse transcriptase.4'-乙炔基-2-氟-2'-脱氧腺苷的糖环构象及其被HIV逆转录酶聚合酶活性位点识别的情况。
Cell Mol Biol (Noisy-le-grand). 2011 Feb 12;57(1):40-6.
2
Selection and evolution of NTP-specific aptamers.NTP特异性适配体的筛选与进化
Nucleic Acids Res. 2004 Sep 27;32(17):5045-58. doi: 10.1093/nar/gkh835. Print 2004.
3
Nucleoside conformation is determined by the electronegativity of the sugar substituent.核苷构象由糖取代基的电负性决定。
Nucleic Acids Res. 1980 Mar 25;8(6):1421-33. doi: 10.1093/nar/8.6.1421.
4
13C NMR relaxation and conformational flexibility of the deoxyribose ring.脱氧核糖环的13C核磁共振弛豫与构象灵活性
Nucleic Acids Res. 1982 Oct 11;10(19):6067-83. doi: 10.1093/nar/10.19.6067.
5
Conformational analysis of the trinucleoside diphosphate 3'd(A2'-5'A2'-5'A). An NMR and CD study.三磷酸二核苷3'd(A2'-5'A2'-5'A)的构象分析。一项核磁共振和圆二色性研究。
Nucleic Acids Res. 1983 Jul 11;11(13):4569-82. doi: 10.1093/nar/11.13.4569.

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Base pairing in DNA.DNA中的碱基配对。
J Mol Biol. 1960 Dec;2:363-71. doi: 10.1016/s0022-2836(60)80047-2.
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Nucleoside conformations: an analysis of steric barriers to rotation about the glycosidic bond.核苷构象：围绕糖苷键旋转的空间位垒分析。
J Mol Biol. 1967 Jul 28;27(2):369-84. doi: 10.1016/0022-2836(67)90026-5.
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Nucleoside antibiotics.
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Conformational analysis of cytidine, 1-beta-D-(arabinofuranosyl)cytosine and their O'-methyl derivatives by proton magnetic resonance spectroscopy.通过质子磁共振波谱法对胞苷、1-β-D-（阿拉伯呋喃糖基）胞嘧啶及其O'-甲基衍生物进行构象分析。
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5
H NMR study of the conformation of the ribose phosphate moiety of 6-azauridine-5'-monophosphate--a nucleotide with an unusual conformation.
FEBS Lett. 1973 Apr 1;31(1):153-5. doi: 10.1016/0014-5793(73)80094-8.
6
Conformational analysis of the sugar ring in nucleosides and nucleotides. Improved method for the interpretation of proton magnetic resonance coupling constants.核苷和核苷酸中糖环的构象分析。解释质子磁共振耦合常数的改进方法。
J Am Chem Soc. 1973 Apr 4;95(7):2333-44. doi: 10.1021/ja00788a038.
7
Crystal structure of the aminoglycosyl antibiotic puromycin dihydrochloride pentahydrate. Models for the terminal 3'-aminoacyladenosine moieties of transfer RNA's and protein-nucleic acid interactions.
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8
A dynamic correlation between ribose conformation and glycosyl torsion angle of dissolved xanthosine studies by continuous-wave-mode and pulsed nuclear-magnetic-resonance methods.
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9
Probing the interrelation between the glycosyl torsion, sugar pucker, and the backbone conformation in C(8) substituted adenine nucleotides by 1H and 1H-(31P) fast Fourier transform nuclear magnetic resonance methods and conformational energy calculations.
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10
Nuclear magnetic resonance studies of 5'-ribo- and deoxyribonucleotide structures in solution.溶液中5'-核糖核苷酸和脱氧核糖核苷酸结构的核磁共振研究。
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溶液中2'-、3'-和5'-脱氧腺苷构象的质子磁共振研究。

Proton magnetic resonance studies of 2'-,3'-, and 5'-deoxyadenosine conformations in solution.

作者信息

Westhof E, Plach H, Cuno I, Lüdemann H D

出版信息

Nucleic Acids Res. 1977 Apr;4(4):939-53. doi: 10.1093/nar/4.4.939.

DOI:10.1093/nar/4.4.939
PMID:301272
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC342496/
Abstract

Proton magnetic resonance studies of 2'-deoxyadenosine (2'-dA), 3'-deoxyadenosine (3'-dA), 5'-deoxyadenosine (5'-dA) and 8-bromo-5'-deoxyadenosine (8-Br-5'-dA) have been carried out in the temperature range between -60 degrees and +40 degrees C for ND3 solutios, +40 degrees and +100 degrees C for D2O solutions, and finally +10 degrees and +60 degrees C for pyridine solutions. The analysis is based on the two-state S in equilibrium N model of the ribose moiety proposed by Altona and Sundaralingam. In all solvents, 2'-dA favours slightly the S state of the ribose and the g+ conformer of the exocyclic CH2OH group. However, 3'-dA prefers strongly the N state of the ribose and the g+ conformation. Both the S and N states of the ribose are equally favoured by 5'-DA and 8-Br-5'-dA. Evidence for the existence of an intramolecular hydrogen bond between 0(5') and N3 in purine (beta)-nucleosides is presented. It is also concluded that cordycepin (3'-dA) exists in solution mainly in the anti conformation of the base relative to the ribose.

摘要

已对2'-脱氧腺苷（2'-dA）、3'-脱氧腺苷（3'-dA）、5'-脱氧腺苷（5'-dA）和8-溴-5'-脱氧腺苷（8-Br-5'-dA）进行了质子磁共振研究，研究温度范围如下：对于ND3溶液为-60℃至+40℃，对于D2O溶液为+40℃至+100℃，最后对于吡啶溶液为+10℃至+60℃。分析基于阿尔托纳（Altona）和孙达拉林加姆（Sundaralingam）提出的核糖部分的双态S处于平衡N模型。在所有溶剂中，2'-dA略微倾向于核糖的S态和环外CH2OH基团的g+构象异构体。然而，3'-dA强烈倾向于核糖的N态和g+构象。5'-DA和8-Br-5'-dA对核糖的S态和N态的偏好程度相同。文中给出了嘌呤（β）-核苷中O(5')与N3之间存在分子内氢键的证据。还得出结论，虫草素（3'-dA）在溶液中主要以碱基相对于核糖的反式构象存在。