[利用气相色谱-质谱联用技术鉴定尿液中的氧甲氢龙代谢物]
[Identification of oxymetholone metabolites in the urine using gas chromatography-mass spectrometry].
作者信息
Lekić M, Sober M, Nikolin B
机构信息
Institut za hemiju, Medicinski fakultet Sarajevo.
出版信息
Med Arh. 1992;46(1-2):5-7.
PMID:1345552
Abstract
Metabolite of 17-methyl-17-hydroxy-2-(hydroxymethylen)-androstan-3-one (oxymetholane) in urine after a single oral administration was monitored by gas chromatography+mass spectrometry. During the investigation prepared TMS-ethers and TMS-enol-ethers of conjugated steroid fraction two new metabolites of oxymetholone have been identified: tetrahydrooxymetholone and tetrahydro-6-hydroxy-oxymetholone.
摘要
采用气相色谱-质谱联用技术监测单次口服17-甲基-17-羟基-2-（羟亚甲基）-雄甾烷-3-酮（羟甲烯龙）后尿液中的代谢产物。在研究过程中，制备了共轭甾体部分的三甲基硅醚和三甲基硅烯醇醚，鉴定出了羟甲烯龙的两种新代谢产物：四氢羟甲烯龙和四氢-6-羟基羟甲烯龙。
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