Kasperlik-Załuska A, Niegowska E, Migdalska B, Jeske W, Zieliński M
Department of Endocrinology, Centre of Postgraduate Medical Education, Warsaw.
Endokrynol Pol. 1992;43(3):314-21.
Correlation analysis was used to investigate the interrelation between plasma ACTH and serum cortisol concentrations determined at 8:00, 12:00, 16:00 and 22:00 h in 48 patients bilaterally adrenalectomized for Cushing's disease, including 23 patients with a pituitary adenoma (Nelson's syndrome). In the patients without evidence of a pituitary adenoma a significant inverse correlation was found at 8:00, 16:00, 22:00 h and additionally when all the pairs of estimations were analyzed. In a full-blown Nelson's syndrome an inverse correlation was not proved (p = 0.05). During remission in Nelson's syndrome an inverse correlation between cortisol and ACTH concentrations was stated at 8:00 h and after the evaluation of all the pairs of estimations. The results of our studies have shown that exogenous cortisol exerts a partial inhibitory action on ACTH secretion in patients bilaterally adrenalectomized for Cushing's disease. In active Nelson's syndrome this influence is questionable, it comes however into prominence during remission.
采用相关性分析研究了48例因库欣病行双侧肾上腺切除术患者（包括23例垂体腺瘤患者，即尼尔森综合征患者）在8:00、12:00、16:00和22:00时测定的血浆促肾上腺皮质激素（ACTH）与血清皮质醇浓度之间的相互关系。在无垂体腺瘤证据的患者中，在8:00、16:00、22:00时以及对所有配对测定值进行分析时均发现显著的负相关。在典型的尼尔森综合征中未证实存在负相关（p = 0.05）。在尼尔森综合征缓解期，在8:00时以及对所有配对测定值进行评估后，皮质醇与ACTH浓度之间存在负相关。我们的研究结果表明，外源性皮质醇对因库欣病行双侧肾上腺切除术的患者的ACTH分泌有部分抑制作用。在活跃的尼尔森综合征中，这种影响存在疑问，但在缓解期则较为突出。
