Elias A N, Gwinup G, Valenta L J
Clin Endocrinol (Oxf). 1981 Aug;15(2):151-4. doi: 10.1111/j.1365-2265.1981.tb00649.x.
Two patients with Nelson's syndrome and one patient after bilateral adrenalectomy for Cushing's disease, without any evidence of Nelson's syndrome, were studied with respect to the effect of hydrocortisone, naloxone and valproic acid (a GABA transaminase inhibitor) on ACTH secretion. Hydrocortisone suppressed plasma ACTH concentrations to normal in the patient without Nelson's syndrome, but failed to do so in the two patients with Nelson's syndrome. Naloxone and valproic acid caused a decline in plasma ACTH concentrations in the patients with Nelson's syndrome, but produced no change in the patient without Nelson's syndrome. Secretion of ACTH may thus be influenced by both opiate peptide and by gamma aminobutyric acid, as well as by the cortisol concentration, these agents may act at different sites to inhibit ACTH release by the tumour.
对两名患有纳尔逊综合征的患者以及一名因库欣病接受双侧肾上腺切除术且无任何纳尔逊综合征迹象的患者，研究了氢化可的松、纳洛酮和丙戊酸（一种γ-氨基丁酸转氨酶抑制剂）对促肾上腺皮质激素（ACTH）分泌的影响。氢化可的松可使无纳尔逊综合征的患者血浆ACTH浓度降至正常水平，但在两名患有纳尔逊综合征的患者中却未能达到这一效果。纳洛酮和丙戊酸可使患有纳尔逊综合征的患者血浆ACTH浓度下降，但对无纳尔逊综合征的患者却无影响。因此，ACTH的分泌可能受到阿片肽、γ-氨基丁酸以及皮质醇浓度的影响，这些物质可能作用于不同位点来抑制肿瘤释放ACTH。
