Batellier J, Tedgui A
Hôpital Beaujon, service de Chirurgie vasculaire et thoracique, Clichy.
Chirurgie. 1992;118(10):659-64.
The parietal thickening of a vein under hemodynamical conditions in the arterial system can be reduced when supporting the vein with a rigid external sleeve. To assess the role of thickness reduction in atherogenesis of an arterialized vein graft, a 4 mm thick external sleeve was implemented around the proximal half of a carotid-carotid vein graft in 16 New Zealand rabbits. Eleven rabbits were submitted to a hypercholesterolemic diet (HC group), while five others were submitted to a normal cholesterol diet (NC group). After eight weeks, a statistically significant difference in thickness was observed between free and sleeved segments, in the NC group with 105 +/- 9 microns versus 65 +/- 6 microns (p < 10.0001) respectively as well as in the HC group with 180 +/- 37 microns versus 99 +/- 35 microns (p < 10.0001) respectively. Studying the extent of soudanophilic lesions showed a statistically significant difference according to the use or not of an external sleeve where average extent is 68 +/- 17% in free segments versus 31 +/- 26% (p < 10.0001) is sleeved segments. The reduction in vein overfullness using an external constrictive sleeve prevents structural parietal changes in the vein and allows reducing atherogenesis of the arterialized vein graft.
在动脉系统的血流动力学条件下，当用刚性外部套管支撑静脉时，静脉的壁增厚可以减轻。为了评估厚度减轻在动脉化静脉移植物动脉粥样硬化形成中的作用，在16只新西兰兔的颈 - 颈静脉移植物近端一半周围实施了一个4毫米厚的外部套管。11只兔子接受高胆固醇饮食（HC组），另外5只接受正常胆固醇饮食（NC组）。八周后，在NC组中，观察到自由段和套管段之间的厚度存在统计学显著差异，分别为105±9微米和65±6微米（p < 0.0001）；在HC组中，分别为180±37微米和99±35微米（p < 0.0001）。研究苏丹ophilic病变的程度表明，根据是否使用外部套管存在统计学显著差异，自由段的平均程度为68±17%，而套管段为31±26%（p < 0.0001）。使用外部收缩套管减少静脉充盈可防止静脉壁结构变化，并有助于减少动脉化静脉移植物的动脉粥样硬化形成。
