实验性糖尿病对大鼠脑内儿茶酚胺代谢的影响。
Effect of experimental diabetes on the catecholamine metabolism in rat brain.
作者信息
Gupta G, Azam M, Baquer N Z
机构信息
Hormone and Drug Research Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
出版信息
J Neurochem. 1992 Jan;58(1):95-100. doi: 10.1111/j.1471-4159.1992.tb09282.x.
The levels of epinephrine, norepinephrine, and dopamine and the activities of tyrosine hydroxylase and monoamine oxidase were estimated in four regions of rat brain during alloxan-induced hyperglycemia and insulin-induced hypoglycemia. Catecholamine levels were estimated by HPLC, and the insulin levels were quantified by radioimmunoassay. The results demonstrated significant increases in the activities of the metabolizing enzymes and levels of catecholamines during experimental conditions. The levels of catecholamines were highest in the cerebral hemispheres, the region associated with high activities of the metabolizing enzymes. Insulin-induced hypoglycemia caused a decrease in the activities of the metabolizing enzymes followed by their recovery within 2 h.
在四氧嘧啶诱导的高血糖症和胰岛素诱导的低血糖症期间，对大鼠脑的四个区域中的肾上腺素、去甲肾上腺素和多巴胺水平以及酪氨酸羟化酶和单胺氧化酶的活性进行了评估。通过高效液相色谱法评估儿茶酚胺水平，通过放射免疫测定法定量胰岛素水平。结果表明，在实验条件下，代谢酶的活性和儿茶酚胺水平显著增加。儿茶酚胺水平在大脑半球中最高，该区域与代谢酶的高活性相关。胰岛素诱导的低血糖症导致代谢酶活性下降，随后在2小时内恢复。
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