Huang H, Huang C F, Huang J S, Wang T C, Jan K Y
Institute of Radiation Biology, National Tsing-Hua University, Taiwan, Tapei, Republic of China.
Int J Radiat Biol. 1992 Jan;61(1):57-62. doi: 10.1080/09553009214550621.
It has previously been reported that chromosome aberrations induced by ultraviolet (UV) radiation can be enhanced by treatment with sodium arsenite for 24 h post-irradiation. Using synchronized CHO-K1 cells, it has now been established that cells in the transitional stage from late G1 to early S phase are most vulnerable to the coclastogenic effect of treatment with UV radiation and arsenite. This result cannot be explained by the special vulnerability of cells in the late G1 to early S transition to UV clastogenicity, as the coclastogenic effects of UV and caffeine or UV and arabinofuranosylcytosine were detected when treating the mid-S but not late-G1 or G2 phase cells.
此前有报道称，紫外线（UV）辐射诱导的染色体畸变在照射后用亚砷酸钠处理24小时可增强。利用同步化的中国仓鼠卵巢细胞（CHO-K1），现已确定，从G1晚期到S期早期的过渡阶段细胞最易受到紫外线辐射和亚砷酸盐联合致断裂作用的影响。这一结果无法用处于G1晚期到S期早期过渡阶段的细胞对紫外线断裂作用的特殊易感性来解释，因为在处理S期中期而非G1晚期或G2期细胞时，检测到了紫外线与咖啡因或紫外线与阿糖胞苷的联合致断裂作用。
