麦角酸二乙胺对P物质的保存作用
The preservation of substance P by lysergic acid diethylamide.
作者信息
KRIVOY W A
出版信息
Br J Pharmacol Chemother. 1957 Sep;12(3):361-4. doi: 10.1111/j.1476-5381.1957.tb00149.x.
Abstract
Lysergic acid diethylamide (LSD) potentiated the response of guinea-pig ileum to substance P but not to histamine. It also inhibited the disappearance of substance P when incubated with guinea-pig brain extract but not when incubated with chymotrypsin. Eserine, morphine, mescaline, chlorpromazine, ergometrine, strychnine and 2 bromo-LSD did not have this effect. Oxytocin was not destroyed by brain extract. The inhibition of the destruction of substance P by LSD could be antagonized by 2 bromo-LSD. This effect of LSD may have some relation to its pharmacological actions.
摘要
麦角酸二乙酰胺（LSD）增强了豚鼠回肠对P物质的反应，但对组胺无此作用。当与豚鼠脑提取物一起孵育时，它还抑制了P物质的消失，但与胰凝乳蛋白酶一起孵育时则没有。毒扁豆碱、吗啡、三甲氧苯乙胺、氯丙嗪、麦角新碱、士的宁和2-溴-LSD没有这种作用。脑提取物不会破坏催产素。LSD对P物质破坏的抑制作用可被2-溴-LSD拮抗。LSD的这种作用可能与其药理作用有关。
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