紫贻贝素对青蛙神经肌肉传递的作用机制。
The mechanism of action of murexine on neuromuscular transmission in the frog.
作者信息
QUILLIAM J P
出版信息
Br J Pharmacol Chemother. 1957 Sep;12(3):388-92. doi: 10.1111/j.1476-5381.1957.tb00153.x.
Murexine (urocanoylcholine, [2-beta-imidazol-4(5)-ylacryloyloxyethyl]trimethylammonium chloride hydrochloride) produced a contracture like acetylcholine in the frog rectus and a neuromuscular block in the rat diaphragm which was not relieved by neostigmine but was antagonized by hexamethonium. Using the foot muscle of the frog, electrical recordings showed that murexine produced a neuromuscular block and depolarized the end-plate region. These effects were similar to those seen with suxamethonium, decamethonium and acetylcholine. While murexine had the same depolarizing potency as decamethonium, it was only one-tenth as active as suxamethonium and acetylcholine. It was concluded that murexine could be classified as a "depolarizing type" of neuromuscular blocking agent but was less potent than suxamethonium.
紫脲酸铵（尿刊酰胆碱，[2-β-咪唑-4（5）-基丙烯酰氧基乙基]三甲基氯化铵盐酸盐）在蛙直肌中产生类似乙酰胆碱的挛缩，在大鼠膈肌中产生神经肌肉阻滞，新斯的明不能缓解这种阻滞，但六甲铵可拮抗它。利用蛙的足部肌肉进行电记录显示，紫脲酸铵产生神经肌肉阻滞并使终板区去极化。这些效应与琥珀酰胆碱、十烃季铵和乙酰胆碱所产生的效应相似。虽然紫脲酸铵具有与十烃季铵相同的去极化效力，但它的活性仅为琥珀酰胆碱和乙酰胆碱的十分之一。得出的结论是，紫脲酸铵可归类为“去极化型”神经肌肉阻滞剂，但效力比琥珀酰胆碱弱。
Zotero 插件