ERSPAMER V, GLASSER A
Br J Pharmacol Chemother. 1958 Dec;13(4):378-84. doi: 10.1111/j.1476-5381.1958.tb00224.x.
Four choline esters of imidazole acids, two imidazole ethers of choline and thirteen ringsubstituted murexine-like compounds were compared with murexine for their muscle-paralysing and their nicotine-like effects. Dihydromurexine appeared, in animal experiments, to be the most potent derivative, but it was shown to be less effective than murexine in man. Among the other compounds, imidazolebutyrylcholine and imidazolepropoxycholine appeared to be worthy of particular consideration. The relation between the chemical structure of the murexine-like substances studied and their pharmacological effects is discussed.
将四种咪唑酸的胆碱酯、两种胆碱的咪唑醚和十三种环取代的紫脲酸胺样化合物与紫脲酸胺进行了比较，研究它们的肌肉麻痹作用和类尼古丁作用。在动物实验中，二氢紫脲酸胺似乎是最有效的衍生物，但在人体实验中，它的效果不如紫脲酸胺。在其他化合物中，咪唑丁酰胆碱和咪唑丙氧基胆碱似乎值得特别关注。本文讨论了所研究的紫脲酸胺样物质的化学结构与其药理作用之间的关系。
