急性氨中毒是由NMDA型谷氨酸受体介导的。

Acute ammonia toxicity is mediated by the NMDA type of glutamate receptors.

作者信息

Marcaida G, Felipo V, Hermenegildo C, Miñana M D, Grisolía S

机构信息

Instituto de Investigaciones Citológicas, Amadeo de Saboya 4, Valencia, Spain.

出版信息

FEBS Lett. 1992 Jan 13;296(1):67-8. doi: 10.1016/0014-5793(92)80404-5.

DOI:10.1016/0014-5793(92)80404-5

PMID:1346118

Abstract

Previous experiments in our laboratory suggested that ammonium toxicity could be mediated by the NMDA type of glutamate receptors. To assess this hypothesis we tested if MK-801, a specific antagonist of the NMDA receptor, is able to prevent ammonium toxicity. Mice and rats were injected i.p. with 12 and 7 mmol/kg of ammonium acetate, respectively. 73% of the mice and 70% of the rats died. However, when the animals were injected i.p. with 2 mg/kg of MK-801, 15 min before ammonium injection, only 5% of the mice and 15% of the rats died. The remarkable protection afforded by MK-801 indicates that ammonia toxicity is mediated by the NMDA receptor.

摘要

我们实验室之前的实验表明，铵毒性可能由NMDA型谷氨酸受体介导。为了评估这一假设，我们测试了NMDA受体的特异性拮抗剂MK-801是否能够预防铵毒性。分别给小鼠和大鼠腹腔注射12和7 mmol/kg的醋酸铵。73%的小鼠和70%的大鼠死亡。然而，当在注射铵前15分钟给动物腹腔注射2 mg/kg的MK-801时，只有5%的小鼠和15%的大鼠死亡。MK-801提供的显著保护表明氨毒性是由NMDA受体介导的。