Goldstein A R, White R H, Akuse R, Chantler C
Department of Nephrology, Children's Hospital, Birmingham, UK.
Lancet. 1992 Feb 1;339(8788):280-2. doi: 10.1016/0140-6736(92)91341-5.
A study of long-term outcome of 78 subjects who had had Henoch-Schönlein nephritis during childhood (at a mean of 23.4 years after onset) shows that severity of clinical presentation and initial findings on renal biopsy correlate well with outcome but have poor predictive value in individuals. 44% of patients who had nephritic, nephrotic, or nephritic/nephrotic syndromes at onset have hypertension or impaired renal function, whereas 82% of those who presented with haematuria (with or without proteinuria) are normal. 17 patients deteriorated clinically from an initial assessment in 1971; 7 of these had apparently completely recovered in 1976. 16 of 44 full-term pregnancies were complicated by proteinuria and/or hypertension, even in the absence of active renal disease. These findings indicate that childhood Henoch-Schönlein nephritis requires long-term follow-up, especially during pregnancy.
一项针对78名儿童期患过敏性紫癜性肾炎患者（发病后平均23.4年）的长期预后研究表明，临床表现的严重程度和肾活检的初始结果与预后密切相关，但对个体的预测价值较差。起病时患有肾炎、肾病或肾炎/肾病综合征的患者中，44%有高血压或肾功能受损，而表现为血尿（伴或不伴蛋白尿）的患者中，82%肾功能正常。自1971年首次评估以来，17例患者临床病情恶化；其中7例在1976年明显完全康复。44例足月妊娠中有16例并发蛋白尿和/或高血压，即使在无活动性肾脏疾病的情况下也是如此。这些发现表明，儿童过敏性紫癜性肾炎需要长期随访，尤其是在妊娠期间。
