Oprițescu Sînziana, Nițescu Gabriela Viorela, Golumbeanu Mihaela, Boghițoiu Dora, Ioniță Elena Iuliana, Licu Monica, Chirigiu Larisa-Marina-Elisabeth, Popovici Violeta, Marin Loredana-Maria, Moroșan Elena
Discipline of Clinical Laboratory and Food Safety, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, Romania.
"Grigore Alexandrescu" Clinical Emergency Hospital for Children, 017443 Bucharest, Romania.
Int J Mol Sci. 2025 Jun 24;26(13):6053. doi: 10.3390/ijms26136053.
Immunoglobulin A vasculitis (IgAV), previously known as Henoch-Schönlein purpura (HSP), is a type of non-thrombocytopenic small-vessel vasculitis. HSP is the most common systemic vasculitis in pediatric patients, and it is characterized by purpura, arthritis or arthralgia, gastrointestinal pain, and renal dysfunction. This retrospective analysis also examines a range of demographic factors, including sex, geographic and environmental influences, age, and medication, to evaluate their potential effects on the pediatric population affected by HSP. The five-year hospital-based retrospective analysis included 138 hospitalized children diagnosed with HSP during hospitalization. Blood sample analysis was conducted to assess various immunological parameters, including levels of immunoglobulins (IgA and IgE), complement components (C3 and C4), C-reactive protein, fibrinogen, the erythrocyte sedimentation rate (ESR), and allergen panels. Elevated IgE levels and normal IgA serum concentrations were found to be strongly associated with infectious diseases in pediatric HSP patients. Patients with recurrent infectious diseases consistently exhibited elevated IgE levels and normal IgA levels during treatment despite no identified allergens, alongside an increased risk of disease recurrence.
免疫球蛋白A血管炎（IgAV），以前称为过敏性紫癜（HSP），是一种非血小板减少性小血管炎。HSP是儿科患者中最常见的系统性血管炎，其特征为紫癜、关节炎或关节痛、胃肠道疼痛和肾功能障碍。这项回顾性分析还研究了一系列人口统计学因素，包括性别、地理和环境影响、年龄和药物治疗，以评估它们对受HSP影响的儿科人群的潜在影响。这项基于医院的五年回顾性分析纳入了138名住院期间被诊断为HSP的儿童。进行了血液样本分析以评估各种免疫参数，包括免疫球蛋白（IgA和IgE）水平、补体成分（C3和C4）、C反应蛋白、纤维蛋白原、红细胞沉降率（ESR）和过敏原检测。研究发现，儿科HSP患者中IgE水平升高和IgA血清浓度正常与传染病密切相关。尽管未发现过敏原，但反复发生传染病的患者在治疗期间始终表现出IgE水平升高和IgA水平正常，同时疾病复发风险增加。
