Bewley S, Bewley T H
Department of Obstetrics and Gynaecology, University College Hospital, London, UK.
Lancet. 1992 Feb 1;339(8788):290-1. doi: 10.1016/0140-6736(92)91344-8.
Dependence on some drugs can be hard to recognize. Hormone replacement therapy (HRT) has been widely prescribed only in the past two decades, and the indications for treatment and the risk/benefit ratio are still disputed. Oestrogens are psychoactive: they lift mood, can be given by injection, and their use has powerful psychological effects. Reports of women with supraphysiological oestradiol concentrations may represent tolerance and withdrawal. Dependence on substances occurring naturally in the body has been reported before. We propose that HRT dependence occurs.
对某些药物的依赖可能难以识别。激素替代疗法（HRT）在过去二十年才被广泛应用，其治疗适应症以及风险/效益比仍存在争议。雌激素具有精神活性：它们能改善情绪，可通过注射给药，其使用具有强大的心理效应。关于雌二醇浓度超生理水平女性的报告可能代表了耐受性和戒断反应。此前已有对体内天然存在物质产生依赖的报道。我们认为激素替代疗法依赖是存在的。
