Carter D M, Jegasothy B V
Arch Dermatol. 1976 Oct;112(10):1397-9.
The skin of 214 institutionalized patients with the Down syndrome was carefully examined. There were 19 cases of alopecia areata and four cases of vitiligo. Since persons with the Down syndrome are predisposed to immunological deficiency in thymus-dependent (T-cell) function, findings from the skin examinations suggest that immunologic factors might contribute to the increased incidence of vitiligo and alopecia areata seen in the Down syndrome. Syringoma was also common and affected female patients twice as frequently as male patients.
对214名患有唐氏综合征的机构收容患者的皮肤进行了仔细检查。有19例斑秃和4例白癜风。由于唐氏综合征患者易患胸腺依赖性（T细胞）功能的免疫缺陷，皮肤检查结果表明免疫因素可能导致唐氏综合征患者中白癜风和斑秃发病率的增加。汗管瘤也很常见，女性患者受影响的频率是男性患者的两倍。
