Ruffner B W
Arch Intern Med. 1976 Sep;136(9):1032-4.
Streptozocin is of value in the treatment of malignant insulinomas, but has not previously been shown to be effective against Zollinger-Ellison tumors, which secrete gastrin. This patient's malignant gastrinoma responded to treatment with streptozocin and fluorouracil. Tumor regression was verified by the disappearance of the epigastric mass, improvement of liver function, and reduction of serum gastrin levels to one third of the pretreatment level. The patient has been in remission for more than two years and has had no further treatment since the first year.
链脲佐菌素在治疗恶性胰岛素瘤方面具有价值，但此前尚未显示对分泌胃泌素的佐林格-埃利森肿瘤有效。该患者的恶性胃泌素瘤对链脲佐菌素和氟尿嘧啶治疗有反应。上腹部肿块消失、肝功能改善以及血清胃泌素水平降至治疗前水平的三分之一，证实了肿瘤消退。该患者已缓解两年多，自第一年以来未再接受进一步治疗。
