用链脲佐菌素成功治疗恶性胃泌素瘤。
Successful treatment of a malignant gastrinoma with streptozotocin.
作者信息
Hayes J R, O'Connell N, O'Neill T, Fennelly J J, Weir D G
出版信息
Gut. 1976 Apr;17(4):285-8. doi: 10.1136/gut.17.4.285.
Abstract
The treatment with streptozotocin of a patient with metastatic gastrinoma is described. Two courses of intravenous streptozotocin were without effect. However, three months after two doses of 4 g streptozotocin were given into the coeliac axis, there was a marked reduction in hepatic size and a fall in fasting plasma gastrin levels from 1430 pmol/l to 240 pmol/l. Seven months after treatment fasting plasma gastrin levels were 125 pmol/l.
摘要
描述了对一名转移性胃泌素瘤患者使用链脲佐菌素的治疗情况。两疗程静脉注射链脲佐菌素均无效果。然而，在经腹腔动脉给予两剂4克链脲佐菌素三个月后，肝脏大小显著缩小，空腹血浆胃泌素水平从1430皮摩尔/升降至240皮摩尔/升。治疗七个月后空腹血浆胃泌素水平为125皮摩尔/升。
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