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1
Successful treatment of a malignant gastrinoma with streptozotocin.用链脲佐菌素成功治疗恶性胃泌素瘤。
Gut. 1976 Apr;17(4):285-8. doi: 10.1136/gut.17.4.285.
2
[Zollinger-Ellison syndrome and metastatic insulinoma; its response to streptozotocin].
Arch Invest Med (Mex). 1977;8(1):31-8.
3
Proceedings: Malignant gastrinoma following total gastrectomy.病例报告：全胃切除术后恶性胃泌素瘤
Arch Surg. 1974 Apr;108(4):444-8. doi: 10.1001/archsurg.1974.01350280050009.
4
Chemotherapy for malignant Zollinger-Ellison tumors: successful treatment with streptozocin and fluorouracil.恶性卓-艾综合征肿瘤的化疗：链脲佐菌素与氟尿嘧啶联合治疗成功
Arch Intern Med. 1976 Sep;136(9):1032-4.
5
Aggressive resection of metastatic disease in selected patients with malignant gastrinoma.对部分恶性胃泌素瘤患者进行转移性疾病的积极切除。
Ann Surg. 1986 Apr;203(4):352-9. doi: 10.1097/00000658-198604000-00003.
6
[Morphology, clinical features, diagnosis, and treatment of Zollinger-Ellison syndrome (author's transl)].卓-艾综合征的形态学、临床特征、诊断及治疗（作者译）
Dtsch Med Wochenschr. 1974 Mar 29;99(13):607-16. doi: 10.1055/s-0028-1107811.
7
[Metastatic malignant pancreatic tumor. Disappearance of symptoms 6 months after streptozotocin treatment (author's transl)].
Ann Endocrinol (Paris). 1973 May-Jun;34(3):293-4.
8
Letter: Streptozotocin in the Zollinger-Ellison syndrome.信函：链脲佐菌素治疗卓-艾综合征
Lancet. 1975 Dec 6;2(7945):1150-1. doi: 10.1016/s0140-6736(75)91045-4.
9
[Zollinger-Ellison syndrome--changes in surgical therapy. Analysis of 27 patients].[佐林格-埃利森综合征——外科治疗的变化。27例患者分析]
Chirurg. 1982 Apr;53(4):263-9.
10
[Endocrine active pancreatic neoplasms].
Helv Chir Acta. 1978 Jan;44(5-6):747-56.

引用本文的文献

1
Intra-arterial use of streptozotocin in a case of metastatic malignant gastrinoma.链脲佐菌素动脉内注射治疗一例转移性恶性胃泌素瘤
Can Med Assoc J. 1981 Dec 15;125(12):1339-41.
2
Gut reactions - control of antral hormone release.本能反应——胃窦激素释放的控制
Ir J Med Sci. 1981 Aug;150(8):230-5. doi: 10.1007/BF02938243.

本文引用的文献

1
Preparation of iodine-131 labelled human growth hormone of high specific activity.高比活度碘-131标记人生长激素的制备
Nature. 1962 May 5;194:495-6. doi: 10.1038/194495a0.
2
Ulcerogenic tumor of the pancreas.胰腺致溃疡肿瘤
Prog Clin Cancer. 1967;3:225-44.
3
Studies of the diabetogenic action of streptozotocin.链脲佐菌素致糖尿病作用的研究。
Proc Soc Exp Biol Med. 1967 Oct;126(1):201-5. doi: 10.3181/00379727-126-32401.
4
Streptozotocin diabetes. Correlation with extent of depression of pancreatic islet nicotinamide adenine dinucleotide.链脲佐菌素糖尿病。与胰岛烟酰胺腺嘌呤二核苷酸抑制程度的相关性。
J Clin Invest. 1974 Sep;54(3):672-7. doi: 10.1172/JCI107805.
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Zollinger-Ellison syndrome.佐林格-埃利森综合征
Gastroenterology. 1973 Jul;65(1):140-65.
6
Pancreatic islet cell carcinoma. II. Results of therapy with streptozotocin in 52 patients.胰岛细胞癌。II. 52例患者接受链脲佐菌素治疗的结果。
Ann Intern Med. 1973 Jul;79(1):108-18. doi: 10.7326/0003-4819-79-1-108.
7
Effects of streptozotocin in a patient with islet cell carcinoma.链脲佐菌素对一名胰岛细胞瘤患者的影响。
Diabetes. 1969 Oct;18(10):675-8. doi: 10.2337/diab.18.10.675.
8
Cushing's syndrome: adrenocortical hyperactivity secondary to neoplasms arising outside the pituitary-adrenal system.
Q J Med. 1966 Apr;35(138):193-214.
9
Proceedings: Malignant gastrinoma following total gastrectomy.病例报告：全胃切除术后恶性胃泌素瘤
Arch Surg. 1974 Apr;108(4):444-8. doi: 10.1001/archsurg.1974.01350280050009.
10
Treatment of multiple-hormone-producing malignant islet-cell tumour with streptozotocin.用链脲佐菌素治疗产生多种激素的恶性胰岛细胞瘤。
Lancet. 1968 Oct 26;2(7574):895-8. doi: 10.1016/s0140-6736(68)91058-1.

用链脲佐菌素成功治疗恶性胃泌素瘤。

Successful treatment of a malignant gastrinoma with streptozotocin.

作者信息

Hayes J R, O'Connell N, O'Neill T, Fennelly J J, Weir D G

出版信息

Gut. 1976 Apr;17(4):285-8. doi: 10.1136/gut.17.4.285.

DOI:10.1136/gut.17.4.285
PMID:178577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1411094/
Abstract

The treatment with streptozotocin of a patient with metastatic gastrinoma is described. Two courses of intravenous streptozotocin were without effect. However, three months after two doses of 4 g streptozotocin were given into the coeliac axis, there was a marked reduction in hepatic size and a fall in fasting plasma gastrin levels from 1430 pmol/l to 240 pmol/l. Seven months after treatment fasting plasma gastrin levels were 125 pmol/l.

摘要

描述了对一名转移性胃泌素瘤患者使用链脲佐菌素的治疗情况。两疗程静脉注射链脲佐菌素均无效果。然而，在经腹腔动脉给予两剂4克链脲佐菌素三个月后，肝脏大小显著缩小，空腹血浆胃泌素水平从1430皮摩尔/升降至240皮摩尔/升。治疗七个月后空腹血浆胃泌素水平为125皮摩尔/升。