Frawley P, Butterworth J F
Nurse Anesth. 1992 Mar;3(1):8-13.
The purpose of this study was to investigate whether magnesium sulfate (MgSO4) at a dose commonly used to treat arrhythmias potentiates vecuronium. After Institutional Review Board approval, 20 randomly assigned, consenting patients received a bolus of either MgSO4 (30 mg/kg) or placebo in a blinded fashion. Immediately after receiving the bolus of either MgSO4 or placebo, the study patients were taken to the operating room (OR) and anesthetized. The ED95 of vecuronium was determined in both groups by administering 10 micrograms/kg boluses of vecuronium until 95% twitch depression was measured. Delay to 25% twitch height recovery (indicating that the neuromuscular block could be reversed for extubation) was measured in 10 patients. Ultrafilterable magnesium levels were measured in a total of 13 patients. Magnesium levels were drawn before the magnesium/placebo bolus, 5 minutes after bolus, and 30 minutes after bolus. The data did not demonstrate any relationship between the use of MgSO4 at 30 mg/kg doses and either the ED95 or the duration of vecuronium. A 30 mg/kg bolus of MgSO4 roughly doubled ultrafilterable magnesium levels from baseline. The limited sample size precluded making any firm conclusions from this data. The data trend suggested that antiarrhythmic doses of MgSO4 may not potentiate vecuronium.
本研究的目的是调查用于治疗心律失常的常用剂量硫酸镁（MgSO4）是否会增强维库溴铵的作用。经机构审查委员会批准后，20名随机分配并同意参与研究的患者以盲法接受了一剂硫酸镁（30mg/kg）或安慰剂。在接受硫酸镁或安慰剂推注后，研究患者立即被送往手术室（OR）并接受麻醉。通过给予10μg/kg的维库溴铵推注直至测量到95%的颤搐抑制，来确定两组维库溴铵的ED95。在10名患者中测量了恢复至25%颤搐高度所需的时间（表明神经肌肉阻滞可被逆转以进行拔管）。总共13名患者测量了可超滤镁水平。在推注镁/安慰剂之前、推注后5分钟和推注后30分钟采集镁水平。数据未显示30mg/kg剂量的硫酸镁使用与维库溴铵的ED95或持续时间之间存在任何关系。30mg/kg的硫酸镁推注使可超滤镁水平从基线大致翻倍。有限的样本量使得无法从这些数据得出任何确凿结论。数据趋势表明，抗心律失常剂量的硫酸镁可能不会增强维库溴铵的作用。
