Okuda T, Umeda T, Takemura M, Shiokawa Y, Koga Y
Department of Anesthesiology, Kinki University School of Medicine, Osaka, Sayama.
Masui. 1998 Jun;47(6):704-8.
The interaction between magnesium sulphate (MgSO4) and vecuronium was investigated during isoflurane-nitrous oxide-oxygen anesthesia. Neuromuscular function was evaluated by recording the single twitch of the abductor policis muscle. Anesthesia was induced with thiamylal followed by injection of vecuronium. The effects of pretreatment with MgSO4 (20 or 40 mg.kg-1) on the potency of vecuronium were compared with observations in patients without MgSO4 pretreatment (control). We also examined the serum concentration of magnesium ions after administration of MgSO4. We found that the neuromuscular effect of vecuronium was not influenced by pretreatment with MgSO4 20 mg. On the contrary, the onset time of vecuronium was decreased and the duration of action until 25% recovery was increased by pretreatment with MgSO4 40 mg. The serum concentration of magnesium ions after administration of MgSO4 40 mg was significantly higher than that after 20 mg. We conclude that pretreatment with MgSO4 40 mg but not 20 mg enhances vecuronium-induced neuromuscular block.
在异氟烷 - 氧化亚氮 - 氧气麻醉期间，研究了硫酸镁（MgSO4）与维库溴铵之间的相互作用。通过记录拇收肌的单次抽搐来评估神经肌肉功能。用硫喷妥钠诱导麻醉，随后注射维库溴铵。将硫酸镁（20或40mg·kg-1）预处理对维库溴铵效能的影响与未用硫酸镁预处理的患者（对照组）的观察结果进行比较。我们还检测了给予硫酸镁后血清镁离子的浓度。我们发现，20mg硫酸镁预处理不影响维库溴铵的神经肌肉效应。相反，40mg硫酸镁预处理可缩短维库溴铵的起效时间，并延长作用持续时间直至恢复25%。给予40mg硫酸镁后血清镁离子浓度显著高于给予20mg后。我们得出结论，40mg而非20mg的硫酸镁预处理可增强维库溴铵诱导的神经肌肉阻滞。
