Coker L A, Mercadal C M, Rouse B T, Moore R N
Department of Microbiology, College of Liberal Arts, University of Tennessee, Knoxville 37996-0845.
J Leukoc Biol. 1992 Mar;51(3):305-6. doi: 10.1002/jlb.51.3.305.
Monoclonal antibody (mAb) depletion was used to assess contributions of CD4+ and CD8+ cells in resistance to systemic murine Candida albicans infection. Depletion of CD8+ cells did not influence either survival or mean survival time (MST); however, depletion of CD4+ cells significantly enhanced both survival and MST. Combined depletion of both CD4+ and CD8+ cells significantly lengthened the MST but did not enhance survival. A protective influence of CD8+ cells could be deduced but, to be manifested, required depletion of an overshadowing immunopathologic CD4+ response.
使用单克隆抗体（mAb）耗竭法评估CD4+和CD8+细胞在抵抗全身性白色念珠菌小鼠感染中的作用。耗竭CD8+细胞对生存率或平均生存时间（MST）均无影响；然而，耗竭CD4+细胞显著提高了生存率和MST。同时耗竭CD4+和CD8+细胞显著延长了MST，但未提高生存率。可以推断出CD8+细胞具有保护作用，但要表现出来，需要消除占主导地位的免疫病理CD4+反应。
