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1
When should asymptomatic patients with HIV infection be treated with zidovudine?感染HIV的无症状患者何时应接受齐多夫定治疗？
BMJ. 1992 Feb 22;304(6825):456-7. doi: 10.1136/bmj.304.6825.456.
2
CD4+ lymphocytes are an incomplete surrogate marker for clinical progression in persons with asymptomatic HIV infection taking zidovudine.对于正在服用齐多夫定的无症状HIV感染者，CD4 + 淋巴细胞是临床进展的不完整替代标志物。
Ann Intern Med. 1993 May 1;118(9):674-80. doi: 10.7326/0003-4819-118-9-199305010-00003.
3
Early treatment for HIV: the time has come.早期治疗艾滋病：时机已至。
N Engl J Med. 1990 Apr 5;322(14):1000-2. doi: 10.1056/NEJM199004053221409.
4
Zidovudine in asymptomatic HIV infection.齐多夫定用于无症状HIV感染。
N Engl J Med. 1993 Dec 16;329(25):1895; author reply 1895-6. doi: 10.1056/NEJM199312163292516.
5
Zidovudine for early human immunodeficiency virus (HIV) infection: who, when, and how?齐多夫定用于早期人类免疫缺陷病毒（HIV）感染：哪些人、何时以及如何使用？
Ann Intern Med. 1990 May 15;112(10):721-3. doi: 10.7326/0003-4819-112-10-721.
6
Long-term zidovudine therapy in patients with AIDS and symptomatic and asymptomatic HIV infection.
Wis Med J. 1991 Apr;90(4):161-5.
7
The duration of zidovudine benefit in persons with asymptomatic HIV infection. Prolonged evaluation of protocol 019 of the AIDS Clinical Trials Group.
JAMA. 1994 Aug 10;272(6):437-42.
8
Zidovudine in asymptomatic HIV infection.齐多夫定用于无症状HIV感染。
N Engl J Med. 1993 Dec 16;329(25):1895; author reply 1895-6.
9
Zidovudine in asymptomatic human immunodeficiency virus infection. A controlled trial in persons with fewer than 500 CD4-positive cells per cubic millimeter. The AIDS Clinical Trials Group of the National Institute of Allergy and Infectious Diseases.齐多夫定用于无症状人类免疫缺陷病毒感染。对每立方毫米CD4阳性细胞少于500个的患者进行的对照试验。美国国立过敏与传染病研究所艾滋病临床试验组。
N Engl J Med. 1990 Apr 5;322(14):941-9. doi: 10.1056/NEJM199004053221401.
10
Zidovudine in persons with asymptomatic HIV infection and CD4+ cell counts greater than 400 per cubic millimeter. The European-Australian Collaborative Group.齐多夫定用于无症状HIV感染者且CD4+细胞计数大于每立方毫米400个的人群。欧洲-澳大利亚协作组。
N Engl J Med. 1993 Jul 29;329(5):297-303. doi: 10.1056/NEJM199307293290501.

引用本文的文献

1
A manual bead assay for the determination of absolute CD4+ and CD8+ lymphocyte counts in human immunodeficiency virus-infected individuals.一种用于测定人类免疫缺陷病毒感染个体中CD4+和CD8+淋巴细胞绝对计数的手工珠粒测定法。
Clin Diagn Lab Immunol. 1995 Sep;2(5):623-5. doi: 10.1128/cdli.2.5.623-625.1995.
2
Partner notification for HIV infection in the United Kingdom: a look back on seven years experience in Newcastle upon Tyne.英国的HIV感染伴侣通知：回顾泰恩河畔纽卡斯尔七年的经验。
Genitourin Med. 1993 Apr;69(2):94-7. doi: 10.1136/sti.69.2.94.
3
Zalcitabine. A review of its pharmacology and clinical potential in acquired immunodeficiency syndrome (AIDS).扎西他滨。对其在获得性免疫缺陷综合征（艾滋病）中的药理学及临床潜力的综述。
Drugs. 1992 Oct;44(4):656-83. doi: 10.2165/00003495-199244040-00009.

本文引用的文献

1
A six-year follow-up of HIV-infected homosexual men with lymphadenopathy. Evidence for an increased risk for developing AIDS after the third year of lymphadenopathy.对患有淋巴结病的HIV感染同性恋男性进行的六年随访。淋巴结病出现三年后患艾滋病风险增加的证据。
JAMA. 1988 Nov 11;260(18):2694-7.
2
Patterns of T lymphocyte changes with human immunodeficiency virus infection: from seroconversion to the development of AIDS.人类免疫缺陷病毒感染时T淋巴细胞变化模式：从血清转化到艾滋病的发展
J Acquir Immune Defic Syndr (1988). 1989;2(1):63-9.
3
Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. Independence of CD4+ cell numbers and clinical staging.在无症状的人类免疫缺陷病毒血清阳性患者中检测到三种不同模式的辅助性T细胞功能障碍。CD4 +细胞数量与临床分期的独立性。
J Clin Invest. 1989 Dec;84(6):1892-9. doi: 10.1172/JCI114376.
4
The relationship between male circumcision and HIV infection in African populations.非洲人群中男性包皮环切术与艾滋病毒感染之间的关系。
AIDS. 1989 Jun;3(6):373-7. doi: 10.1097/00002030-198906000-00006.
5
Effect of stage of disease and drug dose on zidovudine susceptibilities of isolates of human immunodeficiency virus.
J Acquir Immune Defic Syndr (1988). 1990;3(8):743-6.
6
The safety and efficacy of zidovudine (AZT) in the treatment of subjects with mildly symptomatic human immunodeficiency virus type 1 (HIV) infection. A double-blind, placebo-controlled trial. The AIDS Clinical Trials Group.齐多夫定（AZT）治疗轻度症状的1型人类免疫缺陷病毒（HIV）感染患者的安全性和有效性。一项双盲、安慰剂对照试验。艾滋病临床试验组。
Ann Intern Med. 1990 May 15;112(10):727-37. doi: 10.7326/0003-4819-112-10-727.
7
Zidovudine in asymptomatic human immunodeficiency virus infection. A controlled trial in persons with fewer than 500 CD4-positive cells per cubic millimeter. The AIDS Clinical Trials Group of the National Institute of Allergy and Infectious Diseases.齐多夫定用于无症状人类免疫缺陷病毒感染。对每立方毫米CD4阳性细胞少于500个的患者进行的对照试验。美国国立过敏与传染病研究所艾滋病临床试验组。
N Engl J Med. 1990 Apr 5;322(14):941-9. doi: 10.1056/NEJM199004053221401.
8
Sources of variability in repeated T-helper lymphocyte counts from human immunodeficiency virus type 1-infected patients: total lymphocyte count fluctuations and diurnal cycle are important.1型人类免疫缺陷病毒感染患者重复T辅助淋巴细胞计数的变异性来源：总淋巴细胞计数波动和昼夜周期很重要。
J Acquir Immune Defic Syndr (1988). 1990;3(2):144-51.
9
Progression of HIV disease in a haemophilic cohort followed for 11 years and the effect of treatment.对一个血友病队列进行11年随访的HIV疾病进展及治疗效果。
BMJ. 1991 Nov 2;303(6810):1093-6. doi: 10.1136/bmj.303.6810.1093.
10
Effect of zidovudine and Pneumocystis carinii pneumonia prophylaxis on progression of HIV-1 infection to AIDS. The Multicenter AIDS Cohort Study.齐多夫定与卡氏肺孢子虫肺炎预防对HIV-1感染进展至艾滋病的影响。多中心艾滋病队列研究。
Lancet. 1991 Aug 3;338(8762):265-9. doi: 10.1016/0140-6736(91)90414-k.

When should asymptomatic patients with HIV infection be treated with zidovudine?

作者信息

Gazzard B G

出版信息

BMJ. 1992 Feb 22;304(6825):456-7. doi: 10.1136/bmj.304.6825.456.

DOI:10.1136/bmj.304.6825.456
PMID:1347712
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1881128/
Abstract
摘要