Bournique C P, Deysson G, Chottard J C
C R Seances Soc Biol Fil. 1976;170(1):20-4.
In the order of decreasing doses, cis-platinum (II) diamine dichloride acting on root meristem of Allium sativum produces first an irreversible metostatic effect quickly followed by lethal effect, then a variable mitodepression accompanied by important chromosomal alterations: numerous disruptions and stickiness. This chromatoclasic effect persists at very low concentrations but stathmodieretic effect is not observed. The chromatoclasic activity of the compound is compared to that of other antitumoral drugs.
按照剂量递减顺序，顺式二氯二氨合铂（II）作用于大蒜根尖分生组织时，首先迅速产生不可逆的诱变效应，随后是致死效应，接着是伴有重要染色体改变的可变有丝分裂抑制：大量断裂和粘连。这种染色体断裂效应在极低浓度下依然存在，但未观察到有丝分裂静止效应。该化合物的染色体断裂活性与其他抗肿瘤药物的活性进行了比较。
