Roberts M J, Cauchi M N
Department of Haematology, Royal Women's Hospital, Melbourne, Australia.
J Reprod Immunol. 1992 Mar;21(2):203-7. doi: 10.1016/0165-0378(92)90025-y.
DNA polymorphisms of the CD46 gene were investigated using a full length cDNA probe and five different restriction enzymes in genomic DNA samples from human fetal tissues and adult peripheral blood leukocytes. A HindIII polymorphism was observed and was classed as Types I, II and III at a ratio of approximately 3.5:2:1, depending on the presence or absence of two polymorphic fragments of 4.5 and 2.0 kb. No variation of polymorphic distribution was evident between the fetal and adult samples. Whether variation in CD46 expression between maternal and fetal tissue is relevant to fetal viability in pregnancy remains to be established.
利用全长cDNA探针和五种不同的限制性内切酶，对来自人类胎儿组织和成人外周血白细胞的基因组DNA样本进行了CD46基因的DNA多态性研究。观察到一种HindIII多态性，根据4.5 kb和2.0 kb两个多态性片段的有无，其分为I型、II型和III型，比例约为3.5:2:1。胎儿和成人样本之间的多态性分布没有明显差异。母体和胎儿组织之间CD46表达的差异是否与妊娠中的胎儿活力相关仍有待确定。
