Ismaeel N A
Department of Microbiology, College of Medicine & Allied Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
J Hosp Infect. 1992 Jan;20(1):35-42. doi: 10.1016/0195-6701(92)90059-u.
Enterococci isolated from different body sites were tested for high-level gentamicin resistance. A total of 139 enterococcal isolates were screened for resistance (minimum inhibitory concentration [MIC] greater than 2000 mg l-1) by a broth-tube method. Twenty-five (18%) were found to exhibit resistance and this was confirmed by agar screening (1000 mg l-1) and agar dilution MIC determinations. The majority of isolates also showed high-level resistance to kanamycin and streptomycin. The remaining isolates showed high-level resistance to gentamicin and kanamycin but not streptomycin. A retrospective clinical review was performed. Most patients had a source of definite or likely infection (78%). Serious infections such as endocarditis or meningitis were not observed during the course of this study. Retrospective clinical data suggest that in cases not involving endocarditis or meningitis, neither infection refractory to therapy nor relapse of infection is a common sequel to infection with gentamicin-resistant enterococci in hospitalized patients.
对从不同身体部位分离出的肠球菌进行了高水平庆大霉素耐药性检测。采用肉汤管法对总共139株肠球菌分离株进行耐药性筛查（最低抑菌浓度[MIC]大于2000 mg l-1）。发现25株（18%）表现出耐药性，这通过琼脂筛查（1000 mg l-1）和琼脂稀释MIC测定得到证实。大多数分离株还对卡那霉素和链霉素表现出高水平耐药性。其余分离株对庆大霉素和卡那霉素表现出高水平耐药性，但对链霉素不耐药。进行了回顾性临床评估。大多数患者有明确或可能的感染源（78%）。在本研究过程中未观察到诸如心内膜炎或脑膜炎等严重感染。回顾性临床数据表明，在不涉及心内膜炎或脑膜炎的病例中，治疗难治性感染或感染复发并非住院患者中耐庆大霉素肠球菌感染的常见后果。
