Arrese Estrada J, Piérard G E
Department of Dermatopathology, University of Liège, Belgium.
Dermatology. 1992;184(1):22-5. doi: 10.1159/000247493.
Verruga peruana and bacillary angiomatosis are two cutaneous diseases characterized by angiomatous growths linked to the presence of rickettsia-like organisms. These lesions are currently considered to be endothelial hyperplasias and to share many features. By immunohistochemistry and computerized image analysis, we studied the presence of factor-XIIIa-positive dendrocytes in these lesions and compared our data with similar research in capillary angiomas and normal skin. Other cell lines were studied by Ulex europaeus and by antibodies to the L1 antigen and to the von Willebrand factor. Dendrocytes were identified in the three types of angiomatous growth. They were numerous and appeared plump, but no more dendritic than in normal skin. Verruga peruana and bacillary angiomatosis should therefore be viewed as combined growths of endothelial cells and dendrocytes. The biological link between these two types of cells is emphasized.
秘鲁疣和杆菌性血管瘤是两种以血管性生长为特征的皮肤疾病，这些血管性生长与类立克次体生物的存在有关。目前认为这些病变是内皮细胞增生，且具有许多共同特征。通过免疫组织化学和计算机图像分析，我们研究了这些病变中因子 XIIIa 阳性树突状细胞的存在情况，并将我们的数据与毛细血管瘤和正常皮肤的类似研究进行了比较。通过荆豆凝集素和针对 L1 抗原及血管性血友病因子的抗体研究了其他细胞系。在三种血管性生长类型中均发现了树突状细胞。它们数量众多且看起来饱满，但与正常皮肤相比，树突状并不更明显。因此，秘鲁疣和杆菌性血管瘤应被视为内皮细胞和树突状细胞的联合生长。强调了这两种细胞类型之间的生物学联系。
