Piérard-Franchimont C, Arrese J E, Nikkels A F, al-Saleh W, Delvenne P, Piérard G E
Department of Dermatopathology, University of Liège, Belgium.
Virchows Arch. 1996 Sep;429(1):43-8. doi: 10.1007/BF00196819.
Factor XIIIa-positive dendrocytes present at the periphery and inside epithelial neoplasms are an heterogeneous group of cells. They are subsets of mesenchymal cells, cancer-associated macrophages and antigen-presenting cells. Factor XIIIa, other tissue transglutaminases, alpha 2-macroglobulin and tumour necrosis factor-alpha represent a complex network of mediators influencing tumour progression in the skin. In the present study we searched for the presence of dendrocytes and alpha 2-macroglobulin deposits inside and in the vicinity of cutaneous carcinomas (90 basal cell carcinomas and 46 squamous cell carcinomas) and malignant melanomas (69 primary and 28 metastatic tumours). We also studied the proliferation of the same neoplasms by Ki-67 immunohistochemistry. Dendrocytes were numerous, abutting on and infiltrating most basal cell carcinomas and thin malignant melanomas. In contrast, they were present in only low numbers or even absent in thick primary malignant melanomas and in their metastases. They appeared unmodified around squamous cell carcinomas compared with the surrounding skin. Extracellular deposits of alpha 2-macroglobulin were often found in locations where dermal dendrocytes were numerous. No correlation was found between the Ki-67 indices of carcinomas and the density of peritumoral dendrocytes. In contrast, negative relationships were found between the Ki-67 indices and the number of dendrocytes present inside basal cell carcinomas and thin malignant melanomas. This study has yielded circumstantial evidence to link the density of factor XIIIa-positive dendritic cells and a low proliferative rate of neoplastic cells in basal cell carcinomas and malignant melanomas.
存在于上皮性肿瘤周边及内部的ⅩⅢa因子阳性树突状细胞是一组异质性细胞。它们是间充质细胞、癌症相关巨噬细胞和抗原呈递细胞的亚群。ⅩⅢa因子、其他组织转谷氨酰胺酶、α2-巨球蛋白和肿瘤坏死因子-α代表了一个影响皮肤肿瘤进展的复杂介质网络。在本研究中，我们探寻了皮肤癌（90例基底细胞癌和46例鳞状细胞癌）及恶性黑色素瘤（69例原发性肿瘤和28例转移瘤）内部及周边是否存在树突状细胞和α2-巨球蛋白沉积。我们还通过Ki-67免疫组化研究了相同肿瘤的增殖情况。树突状细胞数量众多，紧邻并浸润大多数基底细胞癌和薄型恶性黑色素瘤。相比之下，它们在厚型原发性恶性黑色素瘤及其转移灶中数量较少甚至不存在。与周围皮肤相比，它们在鳞状细胞癌周围未见改变。α2-巨球蛋白的细胞外沉积物常出现在真皮树突状细胞数量众多的部位。未发现癌组织的Ki-67指数与肿瘤周围树突状细胞密度之间存在相关性。相反，在基底细胞癌和薄型恶性黑色素瘤内部，发现Ki-67指数与树突状细胞数量呈负相关。本研究提供了间接证据，表明基底细胞癌和恶性黑色素瘤中ⅩⅢa因子阳性树突状细胞的密度与肿瘤细胞的低增殖率有关。
