Miyakawa T, Katsuragi S, Yamashita K, Araki K, Hashimura T, Kimura T, Ohuchi K
Department of Neuropsychiatry, Kumamoto University Medical School, Japan.
Virchows Arch B Cell Pathol Incl Mol Pathol. 1992;61(5):331-5. doi: 10.1007/BF02890435.
In this immunohistopathological study alpha 1-antichymotrypsin, which is barely demonstrable in the normal brain, was found in amyloid fibrils, endothelial cells and the cytoplasm of astroglial cells in brains from patients with Alzheimer's disease. Amyloid precursors stained with methenamine silver were arrayed mainly along the membranes, and amyloid fibrils, which stained densely with anti-alpha 1-antichymotrypsin, were in direct contact with the fibrous structures connecting with the membranes of vascular feet or astrocytic processes. From the above findings, alpha 1-antichymotrypsin seems to play a role in the production of amyloid fibrils in Alzheimer's disease.
在这项免疫组织病理学研究中，在正常大脑中几乎无法检测到的α1-抗糜蛋白酶，在阿尔茨海默病患者大脑的淀粉样纤维、内皮细胞和星形胶质细胞的细胞质中被发现。用六胺银染色的淀粉样前体主要沿膜排列，而用抗α1-抗糜蛋白酶染色浓密的淀粉样纤维，与连接血管足或星形胶质细胞突起膜的纤维结构直接接触。根据上述发现，α1-抗糜蛋白酶似乎在阿尔茨海默病淀粉样纤维的产生中起作用。
