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大鼠不同肌肉注射的局部效应比较。

A comparison of the local effects of various intramuscular injections in the rat.

作者信息

PAGET G E, SCOTT H M

出版信息

Br J Pharmacol Chemother. 1957 Dec;12(4):427-33. doi: 10.1111/j.1476-5381.1957.tb00160.x.

DOI:10.1111/j.1476-5381.1957.tb00160.x
PMID:13489169
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1510583/
Abstract

A method is described for the assessment of the local reaction produced by intramuscular injections. This method involves the histological examinations of the injection site after injection of material into the hamstring muscles of the rat. The results obtained with both aqueous and oily materials are described; the correlation of these results with clinical observations in man is discussed.

摘要

本文描述了一种评估肌肉注射产生的局部反应的方法。该方法包括将材料注射到大鼠的腘绳肌后，对注射部位进行组织学检查。文中描述了水性材料和油性材料的实验结果，并讨论了这些结果与人体临床观察结果的相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ef3/1510583/0e0a9e5e8b17/bripharmchem00144-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ef3/1510583/23e5ccbe7338/bripharmchem00144-0042-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ef3/1510583/0e0a9e5e8b17/bripharmchem00144-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ef3/1510583/23e5ccbe7338/bripharmchem00144-0042-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ef3/1510583/0e0a9e5e8b17/bripharmchem00144-0044-a.jpg

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引用本文的文献

1
Evaluation of Volume of Intramuscular Injection into the Caudal Thigh Muscles of Female and Male BALB/c Mice ().对雌性和雄性BALB/c小鼠尾侧大腿肌肉进行肌内注射的体积评估（）。
J Am Assoc Lab Anim Sci. 2018 Jan 1;57(1):35-43.
2
[Muscular injuries due to aqueous pharmaceutical solutions determined by transaminase (GOT) liberation].[通过转氨酶（谷草转氨酶）释放量测定水性药物溶液所致的肌肉损伤]
Klin Wochenschr. 1959 Nov 15;37:1189-92. doi: 10.1007/BF01491362.
3
Predicting injection site muscle damage. I: Evaluation of immediate release parenteral formulations in animal models.

本文引用的文献

1
Histological reactions to injections of procaine penicillin in oil.对油剂普鲁卡因青霉素注射的组织学反应。
Br Med J. 1950 Jun 24;1(4668):1467-8. doi: 10.1136/bmj.1.4668.1467.
2
[Symptomatology and pathology of peripheral nerve damage caused by sulfonamides].[磺胺类药物所致周围神经损伤的症状学与病理学]
Nervenarzt. 1952 Jan;23(1):17-21.
3
Local effects and mechanism of absorption of iron preparations administered intramuscularly.肌肉注射铁制剂的局部效应及吸收机制
预测注射部位肌肉损伤。I：动物模型中速释肠胃外制剂的评估。
Pharm Res. 1996 Oct;13(10):1507-13. doi: 10.1023/a:1016075412098.
4
An in vitro model to evaluate muscle damage following intramuscular injections.一种用于评估肌肉注射后肌肉损伤的体外模型。
Pharm Res. 1989 Feb;6(2):167-70. doi: 10.1023/a:1015940811827.
Br J Pharmacol Chemother. 1957 Mar;12(1):107-14. doi: 10.1111/j.1476-5381.1957.tb01371.x.
4
The response of the normal, the denervated and the dystrophic muscle-cell to injury.正常、去神经支配及营养不良的肌细胞对损伤的反应。
J Pathol Bacteriol. 1956 Jul;72(1):273-98. doi: 10.1002/path.1700720134.
5
[Problems and technics of intragluteal injections. I. Effects of the drug and the individuality of the patient on the etiology of injection injuries].[臀肌内注射的问题与技术。I. 药物作用及患者个体因素对注射损伤病因的影响]
Schweiz Med Wochenschr. 1955 Nov 19;85(47):1138-44.
6
[Nerve lesions after intragluteal injection of irgapyrin and a suggestion for their prevention].[臀内注射伊加匹林后的神经损伤及其预防建议]
Schweiz Med Wochenschr. 1955 Nov 5;85(45):1092-6; concl.