Svendsen O, Blom L
Arch Toxicol Suppl. 1984;7:472-5. doi: 10.1007/978-3-642-69132-4_96.
An intramuscular injection was given to rabbits with the needle inserted in the longissimus dorsi muscle. The muscle tissue at the injection site was examined post-mortem 3 days after the injection and areas of necrotic muscle tissue were dissected for weighing. With a fixed dose of the neuroleptic drug cis(Z)-clopenthixol it was shown that a small volume of a concentrated solution caused less muscle damage than a larger volume of a relatively less concentrated solution. Injection speed, on the other hand, was not an important factor. Aqueous solutions of neuroleptic drugs caused local muscle damage which was diminished or prevented by oily vehicles.
将兔子的臀大肌作为注射部位进行肌肉注射。在注射后3天进行尸检，检查注射部位的肌肉组织，并对坏死肌肉组织区域进行解剖称重。使用固定剂量的抗精神病药物顺式（Z）-氯普噻吨，结果显示，小体积的浓缩溶液比大体积的相对稀释溶液造成的肌肉损伤更小。另一方面，注射速度不是一个重要因素。抗精神病药物的水溶液会引起局部肌肉损伤，而油性载体可减轻或预防这种损伤。
