尼古丁、六甲铵和乙醇对大鼠抗利尿激素及催产素分泌的影响。
The effects of nicotine, hexamethonium and ethanol on the secretion of the antidiuretic and oxytocic hormones of the rat.
作者信息
BISSET G W, WALKER J M
出版信息
Br J Pharmacol Chemother. 1957 Dec;12(4):461-7. doi: 10.1111/j.1476-5381.1957.tb00166.x.
Abstract
The actions of nicotine, hexamethonium, and ethanol on the hypothalamo-hypophysial system have been investigated in the rat. The antidiuretic action of nicotine was not inhibited by ethanol, nor by doses of hexamethonium which were sufficient to block both its pressor and convulsant actions. Hexamethonium itself had an antidiuretic action the mechanism of which has been investigated. Nicotine caused a release of oxytocin into the blood which was not blocked by ethanol nor significantly reduced by hexamethonium. The results suggest that any synapse which exists at the supraoptic nuclei is dissimilar in its pharmacological properties to synapses at autonomic ganglia.
摘要
已在大鼠身上研究了尼古丁、六甲铵和乙醇对下丘脑 - 垂体系统的作用。尼古丁的抗利尿作用既不被乙醇抑制，也不被足以阻断其升压和惊厥作用的六甲铵剂量所抑制。六甲铵本身具有抗利尿作用，其作用机制已被研究。尼古丁可使催产素释放到血液中，这一过程既不被乙醇阻断，也不被六甲铵显著降低。结果表明，视上核处存在的任何突触在药理学特性上与自主神经节处的突触不同。
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