未麻醉泌乳大鼠中催产素的释放
Release of oxytocin in unanaesthetized lactating rats.
作者信息
CHAUDHURY R R
出版信息
Br J Pharmacol Chemother. 1961 Dec;17(3):297-304. doi: 10.1111/j.1476-5381.1961.tb01116.x.
The action of certain substances on the release of oxytocin has been studied in unanaesthetized lactating rats. The release of oxytocin has been assessed by the increase in weight after suckling of rats separated overnight from the mother. A large variety of substances appear to block the release of oxytocin. These include pentolinium, atropine and chlorpromazine. Adrenaline and noradrenaline also cause a block in the release of oxytocin, and it is suggested that adrenaline blocks the central release of oxytocin as well as blocking its peripheral action. Reserpine and oestradiol in the doses administered did not block the release of oxytocin. Block also occurred after the ingestion of water, ethanol and normal saline, an effect which may be produced indirectly by impulses from the gastro-intestinal tract.
已在未麻醉的泌乳大鼠中研究了某些物质对催产素释放的作用。通过将与母亲分开过夜的大鼠哺乳后体重增加来评估催产素的释放。各种各样的物质似乎会阻断催产素的释放。这些物质包括潘托铵、阿托品和氯丙嗪。肾上腺素和去甲肾上腺素也会导致催产素释放受阻，有人认为肾上腺素既阻断催产素的中枢释放，也阻断其外周作用。所给予剂量的利血平和雌二醇并未阻断催产素的释放。摄入水、乙醇和生理盐水后也会出现阻断现象，这种效应可能是由胃肠道的冲动间接产生的。
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