BAYLISS B J, ELKES J, SPANNER S G, TODRICK A
Br J Pharmacol Chemother. 1957 Dec;12(4):536-9. doi: 10.1111/j.1476-5381.1957.tb00179.x.
The effect of a previous injection of an anticholinesterase, dyflos, on the sensitivity of rats to two centrally acting drugs, pentobarbitone and leptazol, has been measured. The sensitivity was determined at 12 and 35 days after birth and in full-grown animals. Though the dose of dyflos was of the order of two-thirds of the LD50, it did not affect the sensitivity of the young animals to sodium pentobarbitone and leptazol administered 20 hours later. The full-grown animals which had received dyflos in arachis oil were more sensitive to sodium pentobarbitone than litter mates which had received an injection of arachis oil only; this difference was significant at the 0.1% level. The dyflos treatment did not significantly affect the sensitivity to leptazol.
已测定先前注射抗胆碱酯酶药双氟磷对大鼠对两种中枢作用药物戊巴比妥和戊四氮敏感性的影响。分别在出生后12天、35天以及成年动物中测定敏感性。尽管双氟磷的剂量约为半数致死量的三分之二，但它并未影响幼龄动物对20小时后给予的戊巴比妥钠和戊四氮的敏感性。在花生油中注射了双氟磷的成年动物比仅注射了花生油的同窝动物对戊巴比妥钠更敏感；这种差异在0.1%水平上具有显著性。双氟磷处理对戊四氮敏感性没有显著影响。
