Agarwal A K, Sankaranarayanan A, Sharma P L
Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh.
Indian J Med Res. 1990 Dec;92:476-9.
Effect of subacute insecticide exposure was studied in male albino mice treated with phosphamidon, propoxur or aldrin at 1/40 LD50 dose intraperitoneally daily for 8 wk. The parameters studies included body weight, pentobarbitone (50 mg/kg) sleeping time, chlorpromazine (6 mg/kg) induced motor incoordination and convulsions induced by leptazol (100 mg/kg) and electrical stimulation (18 mA for 0.2 msec). While body weight and electrically induced convulsions were not affected, the effect of various drugs was significantly decreased. The observed changes may be due to the induction of hepatic drug metabolising enzymes by the insecticides. The study suggests that certain dose adjustment of drugs may be necessary in those exposed to insecticides over long periods.
研究了雄性白化小鼠亚急性接触杀虫剂的影响，这些小鼠每天腹腔注射1/40 LD50剂量的磷胺、残杀威或艾氏剂，持续8周。所研究的参数包括体重、戊巴比妥（50毫克/千克）睡眠时间、氯丙嗪（6毫克/千克）诱导的运动不协调以及由戊四氮（100毫克/千克）和电刺激（18毫安，持续0.2毫秒）诱导的惊厥。虽然体重和电诱导惊厥未受影响，但各种药物的作用显著降低。观察到的变化可能是由于杀虫剂诱导肝药物代谢酶所致。该研究表明，长期接触杀虫剂的人群可能需要对药物进行一定的剂量调整。
