外源性化学物质的免疫毒性效应分析。

Analysis of the immunotoxic effects of xenobiotics.

Procházková J

Reference Laboratory for Immunotoxicology, Regional Institute of Hygiene, Hradec Králové, Czechoslovakia.

Hum Exp Toxicol. 1992 Mar;11(2):65-70. doi: 10.1177/096032719201100201.

Abstract

Current problems in immunotoxicology are reviewed with special attention to the sensitivity of the immune system to the effects of xenobiotics. 2. Sensitivity of target cells, route of exposure, dosage, mechanism of action and response of the immune system are discussed as the main factors responsible for the ultimate effects of drugs and chemicals. 3. The methodology of immunotoxicology is divided into two main steps: preclinical screening and the monitoring of exposed persons. 4. Conclusions are prescribed about future tasks in human immunotoxicology.

摘要

本文综述了免疫毒理学当前存在的问题，特别关注免疫系统对外源化学物作用的敏感性。2. 讨论了靶细胞的敏感性、暴露途径、剂量、作用机制以及免疫系统的反应，这些是决定药物和化学物质最终效应的主要因素。3. 免疫毒理学方法主要分为两个步骤：临床前筛查和对暴露人群的监测。4. 针对人类免疫毒理学未来的任务给出了结论。