de Silva H J, Wijewickrema R, Senanayake N
Department of Medicine, Faculty of Medicine, University of Peradeniya, Kandy, Sri Lanka.
Lancet. 1992 May 9;339(8802):1136-8. doi: 10.1016/0140-6736(92)90733-j.
Acute organophosphorus (OP) poisoning is usually treated with atropine plus cholinesterase reactivators such as oximes, but controlled trials to assess the efficacy of oximes in OP poisoning have not been done. A period when the acetyl cholinesterase reactivator pralidoxime chloride was not available in Sri Lanka gave us the opportunity to compare atropine alone for treatment of moderate to severe OP poisoning (21 patients) with atropine plus pralixodime (24 patients). Outcome, as assessed clinically, was similar in the two groups. These results cast doubt on the necessity of cholinesterase reactivators for treatment of acute OP poisoning.
急性有机磷（OP）中毒通常用阿托品加肟类等胆碱酯酶复活剂治疗，但尚未进行评估肟类在OP中毒中疗效的对照试验。在斯里兰卡无法获得乙酰胆碱酯酶复活剂氯解磷定的时期，我们有机会比较单独使用阿托品治疗中度至重度OP中毒（21例患者）与阿托品加氯解磷定（24例患者）的疗效。临床评估的结果在两组中相似。这些结果使人怀疑胆碱酯酶复活剂对治疗急性OP中毒的必要性。
