环糊精及其衍生物与有毒有机磷化合物的相互作用。
Interactions of cyclodextrins and their derivatives with toxic organophosphorus compounds.
作者信息
Letort Sophie, Balieu Sébastien, Erb William, Gouhier Géraldine, Estour François
机构信息
Normandie Université, COBRA, UMR 6014 et FR 3038, Université de Rouen, INSA de Rouen, CNRS, 1 rue Tesnière, 76821 Mont-Saint-Aignan Cedex, France.
出版信息
Beilstein J Org Chem. 2016 Feb 5;12:204-28. doi: 10.3762/bjoc.12.23. eCollection 2016.
The aim of this review is to provide an update on the current use of cyclodextrins against organophosphorus compound intoxications. Organophosphorus pesticides and nerve agents play a determinant role in the inhibition of cholinesterases. The cyclic structure of cyclodextrins and their toroidal shape are perfectly suitable to design new chemical scavengers able to trap and hydrolyze the organophosphorus compounds before they reach their biological target.
本综述的目的是提供关于环糊精目前在对抗有机磷化合物中毒方面应用的最新情况。有机磷农药和神经毒剂在抑制胆碱酯酶方面起决定性作用。环糊精的环状结构及其环形形状非常适合设计新型化学清除剂，能够在有机磷化合物到达其生物靶点之前将其捕获并水解。
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