帕金森病中对重复多巴胺能刺激的运动反应
Motor response to repeated dopaminergic stimulation in Parkinson's disease.
作者信息
Obeso J A, Luquin M R, Grandas F, Vaamonde J, Laguna J, Martinez-Lage J M
机构信息
Department of Neurology, Clinica Universitaria, Medical School, Pamplona, Spain.
出版信息
Clin Neuropharmacol. 1992 Feb;15(1):75-9. doi: 10.1097/00002826-199202000-00011.
Recent studies giving subcutaneous apomorphine or intravenous levodopa boluses have not found clear evidence of behavioral hyposensitivity to repeated dopaminergic stimulation in Parkinson's disease (PD). Here we analyze that data, and review experimental findings in animal models and our previous experience with parkinsonian patients. We conclude that acute tolerance to pulsatile stimulation is likely to play a role in the pathophysiology of motor fluctuations in PD.
近期有关皮下注射阿扑吗啡或静脉推注左旋多巴的研究并未发现帕金森病（PD）患者对重复多巴胺能刺激存在行为低敏性的明确证据。在此，我们分析这些数据，并回顾动物模型中的实验结果以及我们之前对帕金森病患者的研究经验。我们得出结论，对脉冲式刺激的急性耐受性可能在帕金森病运动波动的病理生理学中起作用。
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