Cohn J N
Department of Medicine, University of Minnesota Medical School, Minneapolis.
Chest. 1992 May;101(5 Suppl):347S-349S. doi: 10.1378/chest.101.5_supplement.347s.
The weak relationship between left ventricular function and exercise capacity in heart failure has stimulated interest in neurohumoral mechanisms as possibly contributing to exercise intolerance. Although chronic activation of neuroendocrine systems is characteristic of heart failure and is accompanied by impaired reflex responsiveness to physiologic stimuli, data from clinical trials do not support the hypothesis that the abnormal neurohumoral state is directly related to exercise intolerance. Thus, these systems may play an important role in the natural history of the disease and its high mortality, but they may not be critical to the impaired exercise capacity.
心力衰竭患者左心室功能与运动能力之间的微弱关系激发了人们对神经体液机制的兴趣，因为这些机制可能导致运动不耐受。虽然神经内分泌系统的慢性激活是心力衰竭的特征，且伴有对生理刺激的反射反应受损，但临床试验数据并不支持异常神经体液状态与运动不耐受直接相关这一假说。因此，这些系统可能在疾病的自然史及其高死亡率中起重要作用，但它们可能并非运动能力受损的关键因素。
